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Phospho ADP-ribosylation

Mono(ADP-Ribosyl)atioii and Phospho(ADP-Ribosylation)Reactions in Eukaryotic Cells... [Pg.518]

Nonenzymic ADP-Ribosylation and Phospho(ADP-Ribosylation) of SpecMc Acceptor Proteins... [Pg.518]

Mono(ADP-Ribsoyl)ation and Phospho(ADP-Ribosylation) Reactions in Eukaryotic Cells 519... [Pg.519]

Phospho(ADP-Ribosylation) A New Type of Covalent Modification in Submitochondrial Particles from Rat Liver ... [Pg.520]

Table 2. ADP-ribosylation and phospho(ADP-ribosylation) of proteins in submitochondrial particles of rat liver. SMP were incubated with 50 tiM substrate at pH 6.5. Further details are described in [11] ... Table 2. ADP-ribosylation and phospho(ADP-ribosylation) of proteins in submitochondrial particles of rat liver. SMP were incubated with 50 tiM substrate at pH 6.5. Further details are described in [11] ...
Neither transfer of single ADPR residues by specific eukaryotic transferases nor the existence of other than ester-type linkages in ADPR protein conjugates were recognized for a number of years [24]. Now, there is increasing evidence that the eukaryotic cell possesses a rather elaborate instrumentarium of ADP-ribosylation reactions to modulate important processes. The use of mono(ADPR) groups for the covalent modification of protein provides a tool that may prove to be as versatile as poly(ADP-ribosyl)ation. In addition to the systems discussed here (alkylated cells, differentiation, tumor promotors), mono(ADP-ribosyl)ation may be involved also in the modulation of protein synthesis [8], in the response to heat shock (M. Jacobson, personal communication), and in glutamine synthesis [25]. Nonenzymic mono(ADP-ribosyl)ation reactions must also be taken into consideration whenever the functions of active (P)ADP-ribose as present in the pyridine nucleotides are studied. Finally, preliminary data may indicate that an additional way to modulate protein functions could be provided by phospho-(ADP-ribosylation) reactions. [Pg.523]

Fig. L ADP-ribosylation, a reversible modification of (arginine) proteins. NADiarginine ADP-ribosyltransferases catalyze the stereospecific ADP-ribosylation and phospho-ADP-ribosylation of arginine residues in proteins. ADP-ribosylarginine hydrolases cleave the ADP-ribosylarginine linkage, releasing ADP-ribose and regenerating arginine. Fig. L ADP-ribosylation, a reversible modification of (arginine) proteins. NADiarginine ADP-ribosyltransferases catalyze the stereospecific ADP-ribosylation and phospho-ADP-ribosylation of arginine residues in proteins. ADP-ribosylarginine hydrolases cleave the ADP-ribosylarginine linkage, releasing ADP-ribose and regenerating arginine.
Serine (hydroxyl) phospho- glycosyl- methyl- phosphopantetheine- ADP-ribosyl 8... [Pg.66]

Phospho adenylylation appears to be a prevailing type of pyridine nucleotide dependent modification present in all major compartments and involving the modification of specific acceptors. It also surpasses ADP-ribosylation, by far, at least under the conditions applied. [Pg.30]

Figure 7.5 Adenosine diphosphate (ADP)-ribosylation biochemical reactions. Mono-ADP-ribosyltransferases (ARTs) and poly-ADP-ribose pol5mierases Poly (PARPs) catalyse the ADP-ribose moiety of NAD transfer to amino acid residues. ADP-ribosyl cyclases generate cyclic ADP-ribose and 2-phospho-cyclic ADP-ribose from NAD and NADP, respectively. Both molecules trigger cyclic ADP-ribose cytosolic Ca " elevation, presumably by activating the ryanodine receptor in the endoplasmic/sarcoplasmic reticulum (RER). SIRTl catalyses a reaction that couples protein deacetylation to NAD hydrolysis. Figure 7.5 Adenosine diphosphate (ADP)-ribosylation biochemical reactions. Mono-ADP-ribosyltransferases (ARTs) and poly-ADP-ribose pol5mierases Poly (PARPs) catalyse the ADP-ribose moiety of NAD transfer to amino acid residues. ADP-ribosyl cyclases generate cyclic ADP-ribose and 2-phospho-cyclic ADP-ribose from NAD and NADP, respectively. Both molecules trigger cyclic ADP-ribose cytosolic Ca " elevation, presumably by activating the ryanodine receptor in the endoplasmic/sarcoplasmic reticulum (RER). SIRTl catalyses a reaction that couples protein deacetylation to NAD hydrolysis.
See other pages where Phospho ADP-ribosylation is mentioned: [Pg.518]    [Pg.521]    [Pg.26]    [Pg.26]    [Pg.30]    [Pg.518]    [Pg.521]    [Pg.26]    [Pg.26]    [Pg.30]    [Pg.545]    [Pg.51]    [Pg.51]    [Pg.545]    [Pg.162]    [Pg.117]    [Pg.4]    [Pg.432]    [Pg.1218]   
See also in sourсe #XX -- [ Pg.518 ]



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