Phosgene results

Isatoic anhydride itself (91-1), when allowed to react with the primary amine (91-2), gives the corresponding amide (91-3), again with the expulsion of carbon dioxide. Treatment of the intermediate with phosgene results in the formation of a quinazolodione ring. There is thus obtained the serotonin blocking compound doperidone (91-4) [101], which is described as a sedative. 

A disadvantage of using g.c. analysis for the determination of phosgene results from frequent degradation of the column owing to the corrosive nature of the gas, particularly in the presence of water. For this reason, the column, packing and other parts may be... 

The more volatile isocyanates (such as the monoisocyanates) are inherently hazardous [651] and it makes little sense, in most cases, to invent or evaluate non-phosgene routes to these compounds on the grounds of toxicity considerations alone. However, isocyanate production from phosgene results in the formation of large quantities of hydrogen chloride, and the isocyanate products may be contaminated with chlorine compounds which are difficult to... 

AlCl3-[emim]Cl ([emim] = l-methyl-3-ethylimidazolium cation), with phosgene results in the rapid and complete removal of oxide impurities (in the form of carbon dioxide) [la]. As... 

The chlorination of VjOj by CQ, has been said to be more effective than that by phosgene, resulting in a build up of phosgene in the products from the CQ reaction [1404b]. However, a very recent isothermal thermogravimetric study has shown that the primary reaction products in these systems (400-570 K) is VOCI3, and not VCl [1586c] ... 

Treatment of Me3SiCN with phosgene results in its cleavage to form... 

The reaction of COClj with methanamide, HCONH, at 0 C in CHCl 3/1,4-dioxane solution gave a compound with an empirical formula of CjH ClNjOj, claimed to be (HC0NH2)2.HC1 [237]. The reaction of a series of Af-(hydroxyalkyl)methanamides with phosgene results in their dehydration to the corresponding isonitriles [634a] ... 

Similarly, reaction of anti-amino ketoximes with phosgene results in the formation of intermediate 2-pyrimidone Ai-oxide derivatives [785] ... 

The reaction of 1,2-epoxycyclohexane with phosgene resulted in the formation of the trans-2-chlorocyclohexyl chloroformate isomer [1052], and tra/w-2,3-epoxybutane, on treatment with COClj, gave a mixture of the erytfiro-stereoisomers of 2-chloro-l-methylpropyl chloroformate [1052],... 

The reactions of Af-silyl-substituted ketimine derivatives with phosgene result in the formation of acyl isocyanates, which trimerize or dimerize under the reaction conditions [1854] ... 

Whereas the reaction of MCjNNHj with phosgene results in the formation of the urea, MejNNHCCOlNHNMej, protection with a silyl group prior to reaction with phosgene results in... 

Dry distillation of iV-cyclopropanoylpyrrolidone over CaO affords 2-cyclopropyl-pyrroline. The mechanism shown (Scheme 68) is consistent with C-labelling results. Treatment of (885) with phosgene results in formation of (886). ... 

Mezlocillin [51481-65-3], antibiotic, 156. Chloroformylation of 1-methanesulfonyl-2-imidazolidinone 153 with phosgene results in the key intermediate, 3-chloro-formyl-l-methanesulfonyl-2-imidazolidinone 154 [121-125]. 

---