Phoma terrestris

Several members of phomactins, a rare cleomane class of diterpenes, were identified from culture filtrate of the marine Deuteromycotina Phoma sp. (Sphaeropsidaceae) isolated from the shell of a Japanese crab, Chionaecetes opilus. The structure of phomactin A (67), the first representative of this series, was elucidated by X-ray analysis [97,98]. The structure of the other representatives was determined on the basis of spectroscopic evidence, X-ray crystallography and chemical conversion [99,100] phomactin B (68 extraction yield 3.5 mg/1), phomactin B1 (69) (a colorless crystal extraction yield 0.07 mg/ml), phomactin B2 (70 extraction yield 1.1 mg/ml), phomactin C (71 a colorless crystal extraction yield 1.6 mg/ml), phomactin D (72 a colorless crystal, extraction yield 0.1 mg/ml), phomactin E (73 extraction yield 1.5 m ml), phomactin F (74 extraction yield 0.04 mg/ml), and phomactin G (75 extraction yield 0.28 mg/ml)). The absolute configurations of phomactins A, B and B1 have been determined. The stereochemistry at C2 of phomactin G is still unknown. A 3-epiphomactin C (Sch 47918) from a Phoma sp. of terrestrial origin has also been described [101,102]. The total synthesis of phomactin D has been reported. ... 

Various fiingi from the genus Phoma were extracted with ethyl acetate and characterized by their chromatographic profiles using a C,g column (photodiode array detector from A = 200-400 nm, monitor at A = 230nm) with a 60-min 100/00/100 water/methanol mobile phase gradient. Marine versus terrestrial strains were differentiated. Two compounds positively identified by thermospray MS were mellein and hydroxymellein [415]. 

Cocculus laurifolius Papaver sormiferum Claviceps paspali Claviceps paspali Penicillium crustosum Cephalosporium aaremonium Penicillium chrysogenum Festuca arundinacea Pseudomonas aureofaciens Doliohothele sphaerioa Phoma lingam Pyrenoohaeta terrestris Deoodon vertidllatus,... 

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