Thienyl ketones

Methyl 2-thienyl ketone, 18,1 i-Methylthiol-3-phthalamidopropane-3,3-dicarboxylic acid, 14, 59 6-Methyluracil, 17, 63 Monochlorumethyl ether, 14, 92 Morland salt, 15, 75 Myristic acid, 18, 84 Myristyl alcohol, 10, 64 Myristyl bromide, 16, 26 16, 37... 

VI. Studies in the Acylation of Mcthyl-2-thienyl Ketone. J. Amer. chem. Soc. 72, 5219 (1950). 

Problem 20.8 Use any necessary inorganic reagents to prepare (a) a,a dimethyIthiophene from CHjCOOCjH, (5) phenyl 2-thienyl ketone from PhCOOH and OHCCHjCHjCHO. <... 

FC acylation and alkylation As pyrroles and furans are not stable in the presence of Lewis acids, which are necessary for FC alkylations and acylations, only thiophene, which is stable in Lewis acids, can undergo these reactions. Thiophene reacts with benzoyl chloride in the presence of aluminium chloride to produce phenyl 2-thienyl ketone. 

Raney nickel reduction of 2-benzyl-5-ethylselenophene (71) yields 1-phenylheptane (72), a conversion analogous to the much used reductive desulfurization of thiophenes (73JGU871). The electrochemical reduction of selenophene-2-carboxylic acid gives a mixture of dimeric products the major product is compound (73). This is in contrast to the 2,5-dihydro derivatives obtained by electrochemical reduction of thiophene and furan carboxylic acids (82CS( 19)95). Wolff-Kishner reduction of 2-selenienyl 2 -thienyl ketone gives, in addition to the expected methylene derivative, 2-(pentenyl)thiophene (72ZOB1780). 

Dithiaoctariedioic acid, AH8l Di-2-thienyl ketone, AO69... 

Phenylpyrimidine, AQ91 Phenyl 2-pyrryl ketone, AT06 Phenylpyruvic acid, AP04 Phenyl 2-thienyl ketone, AS92 Phenylthioacetonitrile, AM4l Phenyl trichloromethyl sulfide,... 

The title compound, 2-(8-dimethylaminooctylthio)-6-isopropyl-3-pirydyl-2-thienyl ketone (222), a potent competitive reversible inhibitor of the enzyme PEP (prolyl endopeptidase which cleaves a variety of oligopeptides in brain and peripheral tissues217), has been synthesized218 by ["CJalkylation of the iV-desmethyl precursor 223 (equation 117). 222 crosses the BBB and inhibits brain PEP in rodents219. It is used in the study of biodistribution and activity of brain proteases by PET to evaluate the roles... 

Acetyl-3-methylthiophene (Methyl 3-methyl-2-thienyl ketone) COCHj CH3... 

Phenyl-(2-thienyl)ketone Potassium cyanide Ammonium carbonate... 

C ftH]uN04 146726-10-5) see Trovafloxacin mesilate ethyl (2K,3/ )-3-phenyl-2-oxiranccarboxylate (CU11 202 126060-73-9) see Docetaxel ethyl 4-phenylpiperidine-4-carboxvlate (Cl4H.i,N02 77-17-8) see Anileridine Diphenoxylate ethyl 2-phcnylpropionate (C, 111402 2510-99-8) see Loxoprofen ethyl phenylpyruvate 4-nitrophenylhydrazone (C 2H 7N,04 33671-11-3) see Niinetazepam 4-ethylphenyl 2-thienyl ketone (C, H,2OS 52779-81-4) see Suprofen ethylphosphonic acid bis(dimethylamide)... 

Conformations, structural parameters, and charge distributions of 2-acetylthiophene 137, di-2-thienyl ketone 170, and higher oligomers 171 and 172 (Figure 41) have been determined by ab initio calculations at the HF/6-31"" level of theory <1998JST(455)131>. 

The newly developed ruthenium catalyst 184, having 2,2-bis(diphenyl-phosphanyl)-l, 1-binaphthyl (BINAP) and 2-picolylamine as ligands, effects asymmetric reduction of/-butyl (2-thienyl) ketone under mild conditions with very high enantioselectivity <2005JA8288>. The (6 )-enantiomer of the complex leads to the (/ )-alcohol with 98% ee (Equation 84). 

SYNS ETHANONE, l-(5-METHYL-2-THIENYL)- KETONE, METHYL 5-METHYL-2-THIENYL... 

Catalyst or with acetyl chloride and aluminum chloride catalyst have been reported. o-Nitrophenyl 2-thienyl ketone has been prepared. ... 

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