Pheromones quorum sensing

Keywords Quorum sensing Cell-cell signalling N-Acylhomoserine lactones Antibacterial agents Bacterial pheromones... 

Table 3 Peptide pheromone (PP) lactone signaling quorum sensing systems. The processed peptides shaded in yellow have to be post-translationally modified to become active...

Bacteriocins are antimicrobial peptides ribosomally synthesized in bacteria. These are classified into four or five classes.136 Class II bacteriocins are heat-stable nonlantibiotic peptides. Unlike lantibiotics described in the next section, class II bacteriocins are less modified disulfide bridge and some N-terminal modifications are known in some class II bacteriocins. It is well known that the biosynthesis of some of the class II bacteriocins is regulated by quorum sensing mediated by inducer peptide pheromones.95,137-1... 

In this article, we will concentrate on cell-to-cell communication in the form of quorum sensing in two unicellular groups, bacteria and yeast. Additionally, we will consider intercellular signaling in one species that is at the boundary between uni-ceUularity and multicellularity, Dictyostelium discoideum. To illustrate the diverse mechanisms of cell-to-cell communication, we will discuss their biologic function, on the one hand, and the molecular details of pheromone synthesis, signal transduction, and transcription regulation in each of these groups, on the other hand. 

Molyneaux JM, Anderson JC, Bashkin JK, Winans SC, 31. Joachimiak A. Structure of a bacterial quorum-sensing transcription factor complexed with pheromone and DNA. Nature 2002 417 971-974. 32. 

Kleerebezem M, Quadri LE, Kuipers OP, de Vos WM. Quorum sensing by peptide pheromones and two-component signal-transduction systems in Gram-positive bacteria. Mol. Microbiol. 1997 24 895-904. 

Ji G, Beavis R, Novick RP. Bacterial interference caused by autoinducing peptide variants. Science 1997 276 2027-2030. Zhang L, Lin J, Ji G. Membrane anchoring of the AgrD N-terminal amphipathic region is required for its processing to produce a quorum-sensing pheromone in Staphylococcus aureus. J. Biol. Chem. 2004 279 19448-19456. 

Posticlure (pheromone of Orgyia postica) AI-2 (bacterial quorum-sensing signal)... 

Williams TC, Nielsen LK, Vickers CE (2013) Engineered quorum sensing using pheromone-mediated cell-to-cell communication in Saccharomyces cerevisiae. ACS Synth Biol 2(3) 136-149. doi 10.1021/sb300110b... 

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