Phenylmethylene

PYRAZOLES, PYRAZOLINES AND PYRAZOLONES] (Vol 20) 4,4p(Phenylmethylene)bis[N,N-diethyl-3-methyl]benzenamine[15008- 36-3]... 

Hydrobenzamide [l-phenyl-7V,7V -bis(phenylmethylene)-methanediamine] [92-29-5] M 298.4, m 101-102°, 107-108°. Crystd from absolute EtOH or cyclohexane/ benzene. Dried under vacuum over P2O5. [Pirrone Gazz Chim Ital 67 534 1937.]... 

A/-5-Chlorosalicylidene, 589 A/-(5-Chloro-2-hydroxyphenyl)phenylmethylene, 589 A/-Cyclohexylidene, 589 A/-f-Butylidene, 589... 

Ozonolysis of 6-(phenylmethylene)-6,7,8,9-tetrahydro-l l//-pyrido[2,l-fi]-quinazolin-11-one in CH2CI2 gave 6,7,8,9-tetrahydro-l l//-pyrido[2,l-fi]-quinazoline-6,11-dione (01H(55)1555). 

Condensation of 6,7,8,9-tetrahydro-l]/f-pyrido[2,]-6]quinazolin-ll-one and PhCHO in boiling AC2O for 48 h yielded a 6-phenylmethylene derivative (01H(55)1555). 

Benzaldehyde (available from Fisher Scientific Company) was distilled before use. It is added at this point to convert any unreacted phenylacetonitrile to the high-boiling a-phenylcinnamonitrile [a-(phenylmethylene)benzeneacetonitrile] (Note 7). 

Ruthenium, [l,3-bis(2,4,6-trimethylphenyl)-2-imidazolidinylidene]dichloro(phenylmethylene) (tricyclohexylphosphine)-,... 

N-Benzylidene-benzylamine N-oxide Benzenemethanamine, N-(phenylmethylene)-, N-oxide (3376-26-9)... 

CijHigClNO S 159878-01-0) see Nelfinavir mesylate 3-[(phenylmethylene)amino]-2-oxazolidinone (C10H10N2O2 4341-14-4) see Furazolidone... 

It has also been shown that dimethylsilyl enolates can be activated by diisopropylamine and water and exhibit a high reactivity toward iV-tosyl imines to give Mannich-type reaction products in the absence of a Fewis acid or a Bronsted acid.51 For example, the reaction of [(1-cyclohexen-l-yl)oxy]dimethylsilane with 4-methyl-A -(phenylmethylene)benzene sulfonamide gave re/-4-methyl-N- (f )-[(15)-(2-oxocyclohexyl)phenyl-methyl] benzenesulfonamide (anti-isomer) in 91% yield stereoselectively (99 1 anti syn) (Eq. 11.30). On the other hand, Fi and co-workers reported a ruthenium-catalyzed tandem olefin migration/aldol and Mannich-type reactions by reacting allyl alcohol and imine in protic solvents.52... 

The disilanickela compound 21 is not effective in the nickel-catalyzed double silylation reaction with styrene. However, the stoichiometric reaction of 21 with styrene afforded 4,5-carboranylene-l,l,3,3-tetramethyl-2-phenylmethylene-1,3-disilacyclopentane 29. A key feature in the 111 NMR spectmm of 29 includes a singlet at 7.71 ppm assigned to the vinyl proton. A characteristic low-frequency 13C NMR resonance at 139.75 ppm provides evidence for a tethered carbon atom of the two silicon moieties. Unambiguous confirmation was provided by X-ray crystallographic analysis of 29. 

Dimethyl mesoxolate Propanedioic acid, oxo-, dimethyl ester (9) (3298-40-6) Dimethyl benzalmalonate Malonic add, benzylidene-, dimethyl ester (8) Propanedioic add, (phenylmethylene)-, dimethyl ester (9) (6626-84-2) Dimethyl sulfide Methyl suflide (8) Methane, thiobis- (9) (75-18-3)... 

Lopez-Rodriguez, M.L., Morcillo, M.J., Rovat, T.K., Fernandez, E., Vicente, B., Sanz, A.M., Hernandez, M. and Orensanz, L. (1999) Synthesis and structure-activity relationships of a new model of arylpiperazines. 4.1-[o-(4-Arylpiperazin-l-yl)alkyl]-3-di-phenylmethylene-2,5-pyrrolidinediones and -3-(9H-fluoren-9-ylidene)-2,5-pyrrolidinediones study of the steric requirements of the terminal amide fragment on 5-HTiA affinity/selectivity. Journal of Medicinal Chemistry, 42,36—49. 

Attempts to detect a thermally populated triplet state ( A ) of 8 by ESR spectroscopy were unsuccessful. This was attributed to the high reactivity of the diradical, which presumably easily abstracts hydrogen atoms in hydrocarbon matrices (to form p-quinodimethane), even at very low temperatures. In this context, the triplet state of /7-phenylenebis(phenylmethylene) has been observed. Apparently, substitution of the carbenic hydrogens of 8 by phenyl groups confers sufficient stability (thermodynamic and perhaps kinetic) to the biradical, which allows its observation. According to variable-temperature ESR spectroscopy, the triplet state of /7-phenylenebis(phenylmethylene) is thermally populated and the singlet state lies 0.5-1 kcal/mol lower in energy [76-79]. 

Contrary to the normal Michael reaction of the chloro ester 1-Me with (di-phenylmethylene)amine (DPMA-H) in methanol (Scheme 29), reaction of DMPA-H with 1-Me in methylene chloride or tetrachloromethane containing sodium hydride proceeded much more slowly and gave the isoquinoline 126 in 26 and 39% yield, respectively (Scheme 42) [60 a]. The structure of 126 was ascertained by X-ray crystallography [60a]. Taking into consideration the stability of the Michael adducts 94 in refluxing CCI4, the reaction mechanism with intermediacy of a formal [4-1-2] cycloadduct 125 which may be formed in either a concerted or, more probably, a two-step domino Michael reaction, has been postulated [60a]. 

Phenyl-N-(phenylmethylene)-l-propen-l-amine 1-Propen-1-amine,... 

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