Phenylisopropylamines hallucinogen

Titeler M, Lyon RA, Glennon RA. (1988). Radioligand binding evidence implicates the brain 5-HT2 receptor as a site of action for LSD and phenylisopropylamine hallucinogens. Psychopharmacology (Berlin). 94(2) 213-16. 

The phenylisopropylamine hallucinogens produce a syndrome that is apparently very similar to the spectrum of effects produced by LSD (Shulgin 1978). One strategy for uncovering a specific hallucinogenic... 

Recent controversy about the recreational abuse and potential therapeutic use of designer drugs has focused attention on MDA (methylenedioxyampheta-mine HCl) and structurally related phenylisopropylamine compounds, including MDMA istructural analogs of the psychomotor stimulant amphetamine and the hallucinogen mescaline, and produce stimulant and/or hallucinogenic effects (Shulgin 1978). 

TABLE 1. Human hallucinogenic potencies of 2,5-dimethoxy-4-substituted phenylisopropylamines ... 

Nelson DL, Lucaites VL, Wainscott DB, et al. Comparison of hallucinogenic phenylisopropylamine binding affinities at cloned human 5-HT2A, 5-HT2B. and 5-HT2C receptors. Naunyn-Schmiedeberg s Arch Pharmacol 1999 359 1-6. 

Phenylalkylamines, the phenylethylamines and the phenylisopropylamines, represent the largest group of classical hallucinogens (29,30). The phenylethylamines are the a-desmethyl counterparts of the phenylisopropylamines as with the indolealkylamines, the presence of the a-methyl group increases ... 

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