Phenylethylmalonic acid ethyl ester

Phenylethylmalonic acid ethyl ester chloride Sodium carbonate N,N-Diethylethylenediamine... 

To a solution of 25.5 g of phenylethylmalonic acid ethyl ester chloride in 100 ml of anhydrous benzene 5.3 g of anhydrous sodium carbonate are added followed by 11.6 g of N,N-diethylethylenediamine in small portion. After the spontaneous heat evolution has subsided the mixture is refluxed for 2 hours until the evolution of carbon dioxide ceases. After cooling the mixture is... 

Fenalamide, a-[[[2-(Diethylamino)ethyl]amino]-carbonylj-a -rlhylberizeneacrlic acid ethyl ester N-[2-(dieth-ylamino)ethylJ 2- thyl 2-phenylmaionamic add ethyl ester ethyl N-[2-(diethy[amino)ethy J-2-ethyl-2-phenylmalon-amate phenylethylmalonic acid (diethylamino)ethylamide ethyl ester Spasmamide. C H NjO, mol wt 334.45. C 68.23%, H 9.04%, N 8,38%. O 14,35%. Smooth muscle relaxant, Prepn Galimberti et aL. U.S. pat. 3.025,317 (1962 to Soc. Ital. Prod. Schering). 

C12H12N2O3. White crystals, m.p. 174°C. Prepared by condensing the ethyl ester of phenylethylmalonic acid with urea. It is a more active hypnotic than barbitone. It and its sodium salt - soluble phenobarbitone - are used as sedatives and in treating epilepsy. 

The phenylethylmalonic acid (diethyl amino) ethylamide ethyl ester (free base) is converted in hydrochloride by bubbling hydrogen chloride into a diethyl ether solution of the free base melting point 71-74°C. 

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