Phenylbutazone nephrotoxicity

Kebuzone is an NSAID that is related to phenylbutazone. Allergic reactions, gastrotoxicity, nephrotoxicity, local reactions with necrosis (1), and liver damage have been reported (SED-11,176) (2). The Japanese authorities have asked that the package insert should indicate that this drug must be used only as a last resort when other anti-inflammatory agents and uricosuric drugs are ineffective (SEDA-12, 83). 

Adverse reactions to mofebutazone are similar to those of the parent drug, phenylbutazone, and include skin reactions, including epidermal necrolysis and bullous drug eruption (1). Gastrotoxicity, hepatotoxicity, nephrotoxicity, edema, headache, and hematological adverse effects (SED-9,145) (2) have been described. 

Although adverse renal effects can occur with any NSAID, phenylbutazone-induced nephrotoxicity has mainly been reported when the drug was taken in association with other anti-inflammatory agents (SED-8,215) or when taken alone in a high dose (29). 

Suxibuzone, a derivative of phenylbutazone, is an NSAID that has been used topically. Skin reactions, gastrotoxi-city, nephrotoxicity, headache, and vertigo have been noted. The carcinogenic potential of suxibuzone in animals has attracted attention (1) and put an end to sales in some countries. 

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