Phentolamine, 260

Phentolamine (87), WB 4101 (88), and the site directed alkylatiag agent, chloroethylclonidine (CEC) (89) have been traditionally used to define a -receptors. Table 6 Hsts the various catecholamines and adrenoreceptor agonists and antagonists. [Pg.534]

Three classes of OA receptor, OA-1—OA-3, have been described on the basis of antagonist sensitivities and location (71). The OA-1 receptor is antagonized by the adrenoceptor antagonist, phentolamine (87) and the OA-2 receptor is blocked by mianserin [24219-97-4] C gH2QN2 (271). The OA-3 receptor is similar to the OA-2 receptor but is found in nerve cord and insect brain. TMP, C22H2gN2 (272) and NC5Z, (273) are more potent... [Pg.566]

OC-Adrenoceptor Blockers. Nonselective a-adrenoceptor blockers (Table 6), such as phentolamine, which block both a - and a2 adrenoceptors, produce vasodilation by antagonizing the effects of endogenous norepinephrine. They also produce severe tachycardia and have been replaced by selective a -adrenoceptor blockers, such as prazosin, terazosin, and doxazosin, which do not usually cause severe tachycardia. [Pg.141]

When clonidine is withdrawn abmpdy, patients may experience a rebound hypertensive phenomenon, whereia blood pressure rises rapidly to a level higher than the predmg level. These patients may experience symptoms of headache, tachycardia, agitation, and nervousness. If rebound hypertension occurs, resumption of clonidine therapy or adrninistration of phentolamine reduces the blood pressure. For clonidine withdrawal, the dose should be reduced gradually over a two-week period. The principal side effects are sedation, dry mouth, drowsiaess, di22iQess, and fatigue. [Pg.143]

Phenoxazin-3-ones synthesis, 3, 1034 Phehprocoumon H NMl 3, 582 Phensuximide as anticonvulsant, 1, 166 Phentolamine... [Pg.742]

FIGURE 9.21 Changes in heart rate (ordinates) for agonist-induced changes in cardiac inotropy (changes in rate of ventricular pressure) in anesthetized cats. Responses shown to isoproterenol (filled circles) and dobutamine (open circles), (a) Response in normal cats shows inotropic selectivity (less tachycardia for given changes in inotropy) for dobutamine over isoproterenol, (b) The inotropic selectivity of dobutamine is reduced by previous a-adrenoceptor blockade by phentolamine. From [61],... [Pg.194]

Norepi = norepinephrine Iso = isoproterenol salb. = salbuta-mol phentol = phentolamine. [Pg.249]

Phentolamine (Regitine) is used for its vasodilating effect on peripheral blood vessels and therefore may be beneficial in the treatment of hypertension caused by... [Pg.210]

C2KH2iCIN20d 67977-79-1) see Latamoxef l>[3-(chloromethyl)-4-hydroxyphenyl]ethanone (CyHyCIO 24085-05-0) see Salbutamol 2-chloromethyl A >imidazoline (C4H7CIN2 50342-08-0) see Antazoline 2-chloromethyl>A >imidazoline hydrochloride (C4H(jCl2N2 13338-49-3) see Phentolamine chloromethy] iodide... [Pg.2331]

Mechanical Response. PTX (5 x 10" to 3 x 10 M) caused a concentration-dependent contraction of the guinea pig vas deferens. The configuration of contractile response indicated the presence of two components, an initial rapid component followed by a second slow component. The first component of the response to PTX was abolished after treatment with Mg (10 mM), Ca -free medium, or ouabain (10 M), but remained almost unaffected by phentolamine (10 M), reserpine, 6-OHDA, atropine, or mecamylamine (10" M). The second component of the response to PTX was also completely inhibited after the incubation in the high or Ca -free medium. Phentolamine, reserpine, or 6-... [Pg.220]

Phentolamine <10 minute <3 minute 5-20 mg IV Tachycardia Used in states of excess adrenergic tone (e.g., pheochromocytoma)... [Pg.171]

Atipamezole Cimetidine Histamine Medetomidine Cionidine Idazoxan Monoxidine p-Aminoclonidine Phentolamine... [Pg.177]

Noradrenergic antagonists such as phenoxybenzamine, phentolamine, and propranolol had no effect on stimulant (amphetamine) self-administration (DeWit and Wise 1977 Risner and Jones 1976 Yokel and Wise 1976). [Pg.105]

DeWit, H., and Wise, R.A. Blockade of cocaine reinforcement in rats with the dopamine receptor blocker pimozide, but not with the noradrenergic blockers phentolamine and phenoxybenzamine. Can J Psychol 31 195-203, 1977. [Pg.121]

Infiltrate involved area with phentolamine 5 mg (in 10 mL normal saline)... [Pg.47]

Phentolamine 5-1 5 mg IV bolus 1-2 minutes 10-30 minutes Tachycardia flushing, headache Catecholamine excess... [Pg.28]

Phentolamine N/A Usually used in combination at variable doses Three times weekly, 24 hours between injections... [Pg.784]

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