Phentolamine hydrochloride

Chemical Name 3-U(4,5-t)ihv6ro-1 H-imida2ol-2-Yl)methvH (A-methylphenyDaminolphenol hydrochloride 

Common Name 2-(m-hydroxy-N-p-tolylanilinomethyl)-2-imida2oline hydrochloride Structural Formula  

N- (p-Methy I pheny I) -m +i y droxy phenylam ine 2-Chloromethylimidazoline HCI Hydrogen chloride 

24 parts of N-(p-methylphenyl)-m -hydroxyphenylamine and 77.52 parts of 2-chloro-methylimidazoline hydrochloride are heated for sixteen hours in an oil bath having a temperature of 150°C, while stirring and introducing a current of nitrogen. The viscous contents of the flask are then cooled to about 100 C, mixed with 400 parts by volume of hot water, and stirred for a short time. 

Chemical Name 3-U(4,5-dihydro-1H-imidazol-2-yl)methyl] (4-methylphenyl1aminol phenol hydrochloride 

Chemical Abstracts Registry No. 73-05-2 50-60-2 (Base) Trade Name Manufacturer 

Chemical Name 3-[[(4,5-dihydro-lH-imida2ol-2-yl)methyl] (4-methylphenyl)aminol phenol hydrochloride 

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Dose. 5 to 10 mg of phentolamine mesylate intravenously. Phentolamine hydrochloride has been given in doses of 200 to 300 mg daily, by mouth. 

Ametazole Hydrochloride Benzthiazide Chlordiazepoxide Dichlorphenamide Hydroxychloroquine Sulphate Methacycline Hydrochloride Phentolamine Hydrochloride Acetarsol... 

Phensedyl, 932 Phensuximide, 889 Phentanyl, 617 Phentermine, 890 (metabolite), 732 Phentermine hydrochloride, 890 Phentolamine, 891 Phentolamine hydrochloride, 891 Phentolamine mesylate, 891 Phentolamine methanesulphonate, 891 Phenurone, 869 Phenyl aminosalicylate, 343 Phenyl hydrate, 884 Phenyl hydride, 380 Phenyl salicylate, 967 Phenylacetamide, 312 Phenylacetamidopenicillanic acid, 390 Phenylacetic acid mustard, 442 Phenylacetone, 350 Phenylacetylglutamine, 877 Phenylacetylurea, 869 Phenylalanine nitrogen mustard, 728 Phenylamine, 356... 

The degradation kinetics of phentolamine hydrochloride were studied over a pH range of 1.2 to 7.2 and in various glycol solutions.The kinetics were determined to be first order over all pH values studied, and a consideration of the ionization constant of the compound indicated that only the protonated form of the compound had been studied. At relatively low acidities, a pH-independent region (pH 3.1. 9) was noted for the hydrolysis, and the kinetics were not affected by the concentration of buffer used. However, the degradation reaction was found to proceed at a much faster rate at a pH of 7.2, and a small dependence of rate constant on the concentration of phosphate in the buffer system was noted. 

Figure 4.14 The effect of ionic strength, pi, on the hydrolytic rate constant, k, for phentolamine hydrochloride in buffer solutions of pH 3.1 and 7.2 at 90°C.

Dose Usual, initial, 10 mg per day, increased gradually to 60 mg per day in divided doses. B. Phentolmine INN, Phentolamine Hydrochloride BAN,... 

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