Phenoxy acids, TCDD

McKinney, J.D., Analysis of TCDD in Environmental Samples. Proceedings of the Conference on Chlorinated Phenoxy Acids and Their Dioxins. In Ecol. Bull. (Stockholm), C. Ramel (ed.), 53-66 (1978). 

Case-control studies have been designed to determine if 2,3,7,8-TCDD exposure results in increased risks for site-specific cancers. Case-control studies have found significant increases in the risk of soft-tissue sarcomas in Swedish agricultural, forestry, and horticultural workers (Eriksson et al. 1981, 1990 Hardell and Eriksson 1988 Hardell and Sandstrom 1979), workers involved in manufacturing and application of phenoxy herbicides (Kogevinas et al. 1995), and New Zealand farmers (Smith et al. 1984a). In the Eriksson et al. (1990) study, the risk ratio of soft-tissue sarcoma was 1.80 (95% 0=1.02-3.18) in subjects exposed to phenoxyacetic acid herbicides and/or chlorophenols. In subjects exposed to phenoxyacetic acid herbicides only or chlorophenols only, the risk ratios were 1.34 (95% 0=0.7-2.56) and 5.25 (95%... 

TCDD forms during the manufacture of 2,4,5-TCP. 2,4,5-TCP has been used in cooling towers and in paper, pulp, and leather processing (Hutzinger et al. 1985). 2,4,5-TCP was used to produce the bactericide hexachlorophene and phenoxy-herbicides like 2,4,5-trichlorophenoxy acids (2,4,5-T). 

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