Phenol skin penetration and detoxification

Consequently, eliminating aU or part of the stratum corneum drastically enhances the absorption of physical and chemical agents that could not have penetrated an intact protective stratum corneum. The ability of a product to penetrate the skin also depends on how it interacts with the corneocytes and the intercellular matrix. At the same molecular weight, a proteolytic product will penetrate the skin more readily than a product that is not proteolytic. The more liposoluble a molecule is, the greater its partition between the vehicle and the skin barrier and as a result its ability to penetrate is improved. Another factor to be taken into account is how solvents interact ethanol diffuses better in the stratum corneum when it is mixed with oil rather than water. How well hydrated the stratum corneum is also plays an essential role in the skin s absorption capacity. When the stratum corneum is hydrated, products can be absorbed up to 10 times more efficiently. Hydration swells 

The lymphatic system, which is highly permeable even to large protein molecules, slowly collects some of the phenol in the interstitial fluid. The total daily volume carried by the lymphatic system is approximately equal to the volume of blood of the same individual. This absorption route is very slow and therefore negligible from a toxicological point of view. 

Phenol penetrates rapidly through the skin and is immediately absorbed by the dermal blood vessels. The metabo-lization and/or excretion sites immediately pick up the phenol that has penetrated into the bloodstream. 

Concentration Adjuvants Formulation, phenol Sequestered in applicator, etc. 

Capillary resorption slowed down by oils, edema, etc. 

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