Phenobarbital-response enhancer module

Sugatani J, Kojima H, Ueda A et al (2001) The phenobarbital response enhancer module in the human bilirubin UDP-glucuronosyltransferase UGT1A1 gene and regulation by the nuclear receptor CAR. Hepatology 33 1232-1238... 

X receptor heterodimer activates the phenobarbital-responsive enhancer module of the CYP2B gene. Molecular and Cellular Biology, 18,... 

Kitagawa C, Ando M, Ando Y et al. Genetic polymorphism in the phenobarbital-responsive enhancer module of the UDP-glucuronosyltransferase lAl gene and irinotecan toxicity. Pharmacogenet Genomics 2005 15 35 1. 

Figure 5.34 Mechanism of induction of CYP2B6 by a chemical such as the drug phenobarbital. This drug activates a nuclear receptor (CAR).This combines with the retinoid X receptor and binds to PBREM, as specific section of the CYP gene, which stimulates the production of CYP2B6 mRNA leading to the production of CYP2B6 protein and enzyme. Abbreviations CAR, constitutive androstane receptor RXR retinoid X receptor PBREM, phenobarbital-responsive enhancer module.

Makinen J, Frank C, Jyrkkarinne J, Gynther J, Carlberg C, Flonkakoski P. Modulation of mouse and human phenobarbital-responsive enhancer module by nuclear receptors. Mol Pharmacol 2002 62 366-378. 

Honkakoski P, Moore R, Washburn KA, et al. Activation by diverse xenochemi-cals of the 51-base pair phenobarbital-responsive enhancer module in the CYP2B10 gene. Mol Pharmacol 1998 53 597-601. 

Honkakoski P, Negishi M. Characterization of a phenobarbital-responsive enhancer module in mouse P450 Cyp2bl0 gene. J Biol Chem 1997 272 14943 19. 

Honkakoski, P., Zelko, I., Sueyoshi, T. and Negishi, M. (1998) The nuclear orphan receptor CAR-retinoid X receptor heterodimer activates the phenobarbital-responsive enhancer module of the CYP2B gene. Molecular and Cellular Biology, 18, 5652-5658. 

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