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Phenobarbital-responsive enhancer module PBREM

Figure 5.34 Mechanism of induction of CYP2B6 by a chemical such as the drug phenobarbital. This drug activates a nuclear receptor (CAR).This combines with the retinoid X receptor and binds to PBREM, as specific section of the CYP gene, which stimulates the production of CYP2B6 mRNA leading to the production of CYP2B6 protein and enzyme. Abbreviations CAR, constitutive androstane receptor RXR retinoid X receptor PBREM, phenobarbital-responsive enhancer module. Figure 5.34 Mechanism of induction of CYP2B6 by a chemical such as the drug phenobarbital. This drug activates a nuclear receptor (CAR).This combines with the retinoid X receptor and binds to PBREM, as specific section of the CYP gene, which stimulates the production of CYP2B6 mRNA leading to the production of CYP2B6 protein and enzyme. Abbreviations CAR, constitutive androstane receptor RXR retinoid X receptor PBREM, phenobarbital-responsive enhancer module.
See other pages where Phenobarbital-responsive enhancer module PBREM is mentioned: [Pg.271]    [Pg.175]    [Pg.194]    [Pg.163]    [Pg.90]    [Pg.83]    [Pg.77]    [Pg.405]    [Pg.570]    [Pg.271]    [Pg.175]    [Pg.194]    [Pg.163]    [Pg.90]    [Pg.83]    [Pg.77]    [Pg.405]    [Pg.570]    [Pg.348]    [Pg.797]   
See also in sourсe #XX -- [ Pg.194 ]

See also in sourсe #XX -- [ Pg.77 ]



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PBREM

Phenobarbital

Phenobarbital response enhancer module

Phenobarbital response enhancer module PBREM)

Phenobarbital response enhancer module PBREM)

Phenobarbital-responsive enhancer module

Response modulation

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