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Phenobarbital response enhancer module PBREM

Figure 5.34 Mechanism of induction of CYP2B6 by a chemical such as the drug phenobarbital. This drug activates a nuclear receptor (CAR).This combines with the retinoid X receptor and binds to PBREM, as specific section of the CYP gene, which stimulates the production of CYP2B6 mRNA leading to the production of CYP2B6 protein and enzyme. Abbreviations CAR, constitutive androstane receptor RXR retinoid X receptor PBREM, phenobarbital-responsive enhancer module. Figure 5.34 Mechanism of induction of CYP2B6 by a chemical such as the drug phenobarbital. This drug activates a nuclear receptor (CAR).This combines with the retinoid X receptor and binds to PBREM, as specific section of the CYP gene, which stimulates the production of CYP2B6 mRNA leading to the production of CYP2B6 protein and enzyme. Abbreviations CAR, constitutive androstane receptor RXR retinoid X receptor PBREM, phenobarbital-responsive enhancer module.
See other pages where Phenobarbital response enhancer module PBREM is mentioned: [Pg.271]    [Pg.175]    [Pg.194]    [Pg.163]    [Pg.90]    [Pg.83]    [Pg.77]    [Pg.405]    [Pg.570]    [Pg.271]    [Pg.175]    [Pg.194]    [Pg.163]    [Pg.90]    [Pg.83]    [Pg.77]    [Pg.405]    [Pg.570]    [Pg.348]    [Pg.797]   
See also in sourсe #XX -- [ Pg.90 ]



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