Phendimetrazine tartrate

Chemical Name 3,4 dimethyl-2-phenylmorphQline bitartrate Common Name 3,4-dimethyl-2-phenyltetrahydro-1,4-oxazine bitartrate Structural Formula  

Trede Name Manufacturer Country Year Introduced 

The starting material is produced by reacting propiophenone with bromine and then reacting the Qf-bromopropiophenone produced with 2-methylaminomethanol. 

and Zeile, K. U.S. Patent 2,997,469 August 22, 1961 assigned to C.H. Boehringer Sohn, Germany 

A mixture of 61 grams 1-phenyl-1-oxo-2-(N-methyl-N-ethanolamino)-propane hydrochloride and 100 cc 98-100% formic acid was refluxed at the boiling point at atmospheric pressure for 45 minutes on an oil bath. Thereafter, the oil bath temperature was increased to 180°C and as much of the excess unreacted formic acid as possible was distilled off. A vigorous evolution of carbon dioxide developed during the distillation, which ceased after approximately 45 additional minutes. The honey-yellow syrup which remained as the distillation residue was worked up by admixing it with about six volumes of water and adjusting the aqueous mixture to alkaline reaction with concentrated sodium hydroxide. An oily phase separated out which was extracted with ether. The ether extract was washed with water and dried over potassium carbonate. The solvent was distilled off and the distillation residue was fractionally distilled in vacuo. The base boils at 132°-133°C at 12 mm. The yield was 93% of theory. Reaction with tartaric acid gave the final product. 

---

Fazidinium bromide Fenoterol hydrobromide Folic acid Halothane Ifenprodil tartrate Ketamine HCI Mema ntine Metaproterenol Norfenefrine Oxaflozane HCI Phendimetrazine tartrate Phentermine HCI Procarbazine HCI Promegestone Pyrovalerone HCI Sulfacytine Sulfalene Trioxsalen N-8romoacetamide Fluazacort... 

Sustained release tablets - 75 mg once/day, in mid-morning. PHENDIMETRAZINE TARTRATE ... 

Mecfianism of Action A phenylalkylamine sympathomimetic with activity similar to amphetamines that stimulates the central nervous system (CNS) and elevates blood pressure (BP) most likely mediated via norepinephrine and dopamine metabolism. Causes stimulation of the hypothalamus. Therapeutic Effect Decreases appetite. Pharmacokinetics The pharmacokinetics of phendimetrazine tartrate has not been well established. Metabolized to active metabolite, phendimetrazine. Excreted in urine. Half-life 2-4 hr. 

---