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Phenacyl alcohol

Table 1. Molecular properties of phenacyl alcohol derivatives... Table 1. Molecular properties of phenacyl alcohol derivatives...
The analysis of a molecule with one site of action is a good indicator for the LD50, such as in phenacyl alcohol derivatives. Steroids, however, are complex molecules, and their metabolites contribute to the experimentally measured LD50 values. If the toxicity can be related to superoxide, the measurement of chemiluminescence intensity can be used for a drug candidate screening. Further studies of the substituent effect of steroids are required before LD50 values can be estimated from computational chemical calculations. [Pg.400]

This method has been used for oxidation of methyl epoxystearate to the corresponding acyloin.393 In more recent work, Tsuji391> reports that the conversion of epoxides into a-hydroxyketones proceeds in better yield by passing air into a solution of the epoxide in DMSO (no BF3). In this way styrene oxide gives phenacyl alcohol in 92% yield. No oxidation occurs in the absence of oxygen, but oxygen is... [Pg.357]

The ape of atoms was correlated with the relative sensitivity of phenacyl alcohol derivatives and steroids. The correlation coefficients for several keto-form steroids varied from 0.221 to 0.842, and for enol forms from 0.163 to 0.800, as summarized in Table 11.3. [Pg.274]

Phenyl iodosotrifluoroacetate added to a soln. of phenacyl iodide in dry dichloro-methane, stirred at room temp, for 17 h, and the crude product subjected to silica gel column chomatography eluting with methanol and dichloromethane phenacyl alcohol. Y 74%. F.e.s. J.H. Boyer, A. Natesh, Synthesis 1988, 980-1. [Pg.338]

Z iroxyphenoxyaeeiopherume, catechol phenacyl r, phenacyl alcohol catechol ether)... [Pg.318]


See other pages where Phenacyl alcohol is mentioned: [Pg.744]    [Pg.744]    [Pg.1341]    [Pg.1341]    [Pg.744]    [Pg.397]    [Pg.398]    [Pg.398]    [Pg.398]    [Pg.744]    [Pg.89]    [Pg.177]    [Pg.21]    [Pg.273]    [Pg.89]    [Pg.177]    [Pg.220]    [Pg.597]    [Pg.779]   
See also in sourсe #XX -- [ Pg.161 ]

See also in sourсe #XX -- [ Pg.8 , Pg.47 ]




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Phenacyl

Phenacyl alcohol derivatives

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