Phase-Sensitive Smart Polymers

Phase-sensitive smart (stimuli responsive, surroxmding environmentally sensitive) polymers offer the development of a controlled delivery system that can deliver the protein and peptides in stable and bioactive form in a controlled manner. Compared to other systems, phase-sensitive polymeric systems have advantages such as low cost, ease of manufacture, high protein and peptides loading capacity, less traumatic manufacturing conditions and the major advantage of phase-sensitive polymeric systems is the lyso-zymal enzyme release. This type of phase-sensitive polymeric system was prepared by incorporating lysozyme enzyme to poly(D,L-lactic acid) (PLA)-triacetin solutions [61]. 

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Polymer colloids have received an increasing interest in various applications and also biomedical areas in which they are mainly used as solid-phase supports of biomolecules. This is due to the versatility of the many heterophase elaboration processes (emulsion, dispersion, precipitation, physical processes) for making well-defined microspheres of appropriate particle sizes and surface reactive groups. In this direction, special attention has been dedicated to the preparation of smart colloids. The principal interest carried to colloidal particles based on alkyl(metha)acrylamide derivative is mainly related to their thermally sensitive colloidal properties. 

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