Pharmacology solubilization effects

Many APIs are marketed in a salt form. Salt formation can confer a variety of physical, chemical, and biological properties on the API without changing its basic chemical structure. A few of the important properties are water solubilization, modified dissolution rates, improved stability, and beneficial pharmacological effects. 

Chemically solubilized active principles render possible the preparation of parenteral, and especially intravenous forms appreciated in the clinical practice. But even at the preclinical level, the use of water-soluble molecules is recommended as they are effectively much easier to study by in vitro tests, in cell or microorganism cultures and on isolated organs. The inconveniences are that chemically modified sfructures may show modified pharmacological, pharmacokinetic and toxicological properties. 

The difficulty in using the xanthines in pharmacy is that they have a pharmacological action of their own and limited solubility. However, a number of medicaments contain hydrotropes for their therapeutic effect and not their solubilizing action, such as in aspirin, phenacetin, and caffeine mixtures it is unlikely that the caffeine in this preparation is inactive. 

---