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Pharmacology of Appetite and Eating

Drugs Reducing Appetite and Food Intake (Anorectics) [Pg.27]

Amphetamine was the first anorectic drug to be introduced into clinical practice. It was originally synthesised in the 1920 s as a potential substitute for ephedrine and marketed under the trade name of Benzedrine for use as a nasal decongestant. Initially, it was thought to have very little, if any, effect on the central nervous system. However, within a relatively short time it was noted that, in contrast to what had first been thought, amphetamine had pronounced stimulant and mood elevating properties. [Pg.27]

The antidepressant drug fluoxetine Prozac), another compound which promotes serotonergic neurotransmission in the brain, was also shown to reduce appetite and food intake in healthy volunteers (McGuirk and Sil-verstone 1990). It can be effective in the management of binge eating syndrome (see Chapter 6) and bulimia nervosa (see Chapter 5). Its use in uncomplicated obesity is more limited, as any beneficial effect wears off within a few months (Goldstein et al. 1994). [Pg.29]

Mazindol has a different chemical structure from the phenylethylamine compounds considered above and a somewhat different pharmacological profile. Rather than promoting release of norepinephrine, it inhibits the neuronal reuptake of norepinephrine in the brain. In healthy human subjects a single oral dose of 1 mg reduces food intake significantly more than placebo for a period of eight hours (Silverstone 1982). [Pg.30]

This group of drugs all have high bioavailabilty, a high distribution volume (4 1/kg), and are less than 20% bound to plasma proteins (de la Torre et al. 2004). Their elimination half-life is 6-12 hours. [Pg.30]


With our increasing understanding of the ways appetite and eating are regulated in humans, even more effective pharmacological treatments of bulimia nervosa are likely to be developed in the relatively near future. [Pg.64]


See other pages where Pharmacology of Appetite and Eating is mentioned: [Pg.27]    [Pg.28]    [Pg.29]    [Pg.30]    [Pg.31]    [Pg.32]    [Pg.33]    [Pg.34]    [Pg.35]    [Pg.36]    [Pg.37]    [Pg.27]    [Pg.28]    [Pg.29]    [Pg.30]    [Pg.31]    [Pg.32]    [Pg.33]    [Pg.34]    [Pg.35]    [Pg.36]    [Pg.37]    [Pg.218]    [Pg.218]    [Pg.290]    [Pg.843]    [Pg.1154]    [Pg.218]    [Pg.157]    [Pg.830]   


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Appetite

Eating

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