Pharmacology antiretrovirals

Hoetelmans RM (1999) Pharmacology of antiretroviral drugs. Antivir Ther 4(Suppl 3) 29 1 Hoffman NG, Schiffer CA, Swanstrom R (2003) Covariation of amino add positions in HlV-1 protease. Virology 314 536-548... 

The same principles of antiretroviral therapy apply to both HIV-infected children and adults, although the treatment of HIV-infected children involves unique pharmacologic, virologic, and immunologic considerations. 

Data from Panel on Clinical Practices for the Treatment of HIV Infection. Guidelines for the Use of Antiretroviral Agents in HIV-Infected Adults and Adolescents. 2006, http/AMM/vAIDSinfo.NIH.gov Anderson PL, Kakuda TN, Lichtenstein KA. The cellular pharmacology of nucleoside- and nudeotide-andogue reverse-transcriptase inhibitors and its relationship to dinical toxdties. din Infect Dis 2004 38 743-753 and produd information for agents... 

Pharmacology Lamivudine/zidovudine combination tablets contain 2 synthetic nucleoside analog reverse transcriptase inhibitors with activity against HIV. Lamivudine in combination with zidovudine has exhibited synergistic antiretroviral activity. Refer to lamivudine and zidovudine individual monographs. Pharmacokinetics One combination lamivudine/zidovudine (150/300 mg) tablet is bioequivalent to a 150 mg lamivudine tablet plus a 300 mg zidovudine tablet. 

Flexner C. 2005. Antiretroviral agents and treatment of HIV infection. In Brunton LL, Ed. Goodman and Gilman s, the Pharmacological Basis of Therapeutics. 11th Ed., The McGraw-Hill Companies. 

This section contains information primarily about the antiviral activity, pharmacology, and treatment of herpesvirus infections. There is limited information on the antiviral treatment of adenovirus infections. The antiretroviral agents used to treat RNA viruses responsible fc>r AIDS are listed and their functions reviewed. However, there is no information on clinical trials pertaining to antiretroviral agents. 

Pharmacological Interactions Between Antiretrovirals and Other Medications with Activity in the Central Nervous System... 

The protease inhibitors (Pis) are a potent class of antiretrovirals that includes amprenavir, atazanavir, fosamprenavir, indinavir, Iopinavir, nelfinavir, ritonavir, and saquinavir. Tipranavir is an investigational PI at the time of this writing. The pharmacology, safety, and efficacy of these drugs are reviewed elsewhere. " Briefly, Pis block the maturation process, thereby resulting in the production of immature, noninfectious virions. ... 

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