Pharmacology antimicrobials

Several biologically and pharmacologically active compounds have been prepared from the condensation of the acid chloride of 1-naphthoxyacetic acid with carbazole, iadole, or pyrrole ia 2A[ NaOH solution ia ethanol (63). Also, naphthyloxy derivatives of imidazole, benzimidazole, and benzotriazoles have been synthesized and screened for their antimicrobial, analgesic, and antiinflammatory activities. 2-Naphthyloxy derivatives are comparatively more active than 1-naphthyloxy derivatives (64). 

Lis-BALCHIN M, HART s, SIMPSON E (2001) Buchu (Aguthosmu betuUna and. crenulata, Rutaceae) essential oils their pharmacological action on guinea-pig ileum and antimicrobial activity on microorganisms. J Pharm Pharmacol. S3 579-82. 

Surgical intervention has become an integral therapy in combination with pharmacologic management of IE. Valve replacement is the predominant intervention, and it is used in a minimum of 25% for all cases of IE.1 Surgery may be indicated if the patient has unresolved infection, ineffective antimicrobial therapy (often associated with fungal IE), more... 

Phthalide derivatives are of pharmacological interest, as they show antitumor [294] and anticonvulsant [295] as well as antimicrobial activity [296] they have also been found to have useful herbicidal activity [297]. 

Tetracyclic /3-carboline alkaloids, known as canthines, have a peri-fused indolo[3,2,Tnaphthyridine structure. Over 40 members of this class of compound have been isolated, and they are of interest on account of their broad range of pharmacological effects (antimicrobial, cytotoxic, antibacterial, anticancer). 

Benzimidazole is an important heterocyclic nucleus in the field of medicinal chemistry. The most prominent benzimidazole compound in nature is N-ribosyldimethylbenzimidazole, which serves as an axial ligand for cobalt in vitamin B12. The versatile nature of benzimidazole makes it a highly explored molecule in medicinal chemistry. A number of pharmacological activities are associated with benzimidazole derivatives such as anthelmintic, antiulcer, antipsychotic, proton pump inhibitor, antianxiety, anti-emetic and sedative, vasodilator, anticancer, analgesic, antihistaminic, antifungal, antiviral and antimicrobial. 

The pharmacological action, antimicrobial spectrum, and indications for use are analogous to those of cefamandole. A synonym of this drug is monocid. 

In terms of pharmacological action, clotrimazole is very similar to miconazole. It has a broad spectrum of antifungal activity. It is effective with respect to dermatophytes, and it also has an antimicrobial effect against streptococci and staphylococci. It is also effective with respect to trichomonases. It is very widely used, both externally and vaginally for treating superficial infections. Synonyms of this drag are canesten, empecid, lotrimin, micosporin, and others. 

Pharmacology BSS appears to have antisecretory and antimicrobial effects in vitro and may have some anti-inflammatory effects. The salicylate moiety provides the antisecretory effect, while the bismuth moiety may exert direct antimicrobial effects against bacterial and viral enteropathogens. 

Pharmacology The tetracyclines are bacteriostatic. They exert their antimicrobial effect by inhibition of protein synthesis. Tetracyclines are active against a wide range of gram-positive and gram-negative organisms. 

Roe VA. Antimicrobial agents pharmacology and clinical application in obstetric, gynecologic, and perinatal infections. J Obstet Gynecol Neonatal Nnrs 1999 28(6) 639-48. 

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