Pharmacological Uses of Thiamin

ApMt from children with thiamin-responsive maple syrup urine disease (Section 6.3.1.4) and thiamin-responsive megaloblastic anemia (Section 6.2), there are no established pharmacological uses of thitimin other than the treatment of deficiency. Because of the neurological involvement in thiamin deficiency, the vitamin has been used in nerve tonics, tilthough there is no evidence that it has any effect except in cases of deficiency. 

Studies in thiamin-deficient animals revealed the presence of Alzheimer-like amyloid plaques in the brain. Although there is no evidence of similar plaque formation in the brains of patients with the Wernicke-Korsakoff syndrome, this has led to trials of thiamin for treatment of Alzheimer s disease 

European Union FAO, Food and Agriculture Organization WFIO, World Flealth Organization. 

Sources Department of Flealth, 1991 Scientific Committee for Food, 1993 Institute of Medicine, 1998 FAO/WHO, 2001. 

Bettendorff L (1996) A non-cofactor role of thiamine derivatives in excitable cells  

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Biochemistry of NAD NAD Used for Nonredox Purpose History of Niacin Nutrition Ass sment of Niacin Static Pharmacological Use of Nicotinic Add Thiamin... 

Use Pharmacologically important P. compounds include the derivatives of barbituric acid, vitamins (thiamine, riboflavin), some diuretics, nucleoside antibiotics, and antimetabolites (antipyrimidines) that are used in cancer therapy (e.g 5-fluorouracil and thio-uracil). 

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