Pharmacological parameter

Table 3 Pharmacological parameters of pegylated IFN-a molecules approved for the treatment of chronic hepatitis C...

In absence of safety pharmacology parameters, the highest doses equal or exceed some adverse effects (toxic range). 

There appears to be no relationship between the antihypertensive activity of the 3-blocking agents and the other three laboratory pharmacological parameters. 

In terms of pharmacological parameters, prilocaine is comparable to lidocaine however, because of a number of toxic manifestations, it is rarely used in medical practice. Citanest and xylonest are well-known synonyms for prilocaine. 

Morelock, M.M., Choi, L.L., Bell, G.L., and Wright, J.L. (1994). Estimation and correlation of drug water solubility with pharmacological parameters required for biological actis/itp.harm. Sci., 83 948-951. 

Alban S, Gastpar R, Plasma levels of total and free tissue factor pathway inhibitor as individual pharmacological parameters of various heparins, Thromb Haemost 2001 85(5) 824-829. 

All these different factors—absorption, distribution, metabolism, and excretion—interact with each other and together determine various pharmacological parameters that have clinical significance ... 

TABLE 18-2 Important Pharmacological Parameters of the Thiazide Diuretics ... 

Dissociation Constants of Choiin-ergics and Antichoiinergics. The absolute configuration [(R) and ( 9)] is self-consistent for a molecule in question and cannot be used to relate a series of compounds. The configuration in relation to a standard substance (d and l) is very useful to compare a series of compounds. For example, the pharmacological parameters of all D compounds in a series can be compared with those of the l compounds, provided each one of the compounds contains a single asymmetric carbon (217). 

Drugs used in psychiatric care that are commonly monitored include antidepressants, some neuroleptics, and Hthium. Pharmacological parameters of these antipsychotic drugs are shown in Table 33-10. 

The aqueous extract of stem bark of M. pterygosperma has been investigated for its effect on various pharmacological parameters. In cardiovascular profile, at lower concentrations the extract produces a dose dependent positive inotropic effect and at higher concentrations (0.1-1 pg) a dose dependent negative inotropic effect on the isolated frog heart is observed. It... 

Why choose a parenteral system This system ensures that the drug will reach specific target areas of the body via blood and lymphatic systems. It allows the researcher to have control over pharmacological parameters,2 serum levels, tissue concentrations, elimination of the drug from the body, and other factors. 

The study was a randomized, stratified, open label, two-arm parallel Phase 4 trial designed to explore the utility of pharmacological parameters as predictors of antiviral response to nelfinavir-containing regimens in patients pretreated with protease inhibitors-sparing regimens. 

I Phase I trials determine basic pharmacological parameters in human volunteers, e.g. pharmacokinetics, adverse effects, tolerance ... 

Ultimately, the potential ofbiologically active substances can only be assessed in actual biological systems by means of animal experiments (Scheme 1-29) and confirmed by subsequent clinical studies. En route to this, however, the dynamic system described here offers various options for the analysis and optimization of pharmacological parameters like affinity and activity. It is the heterobifunctional character of the dynamic system that allows the synthetic chemist to influence both intrinsic self-assembly as well as extrinsic molecular recognition in a controlled way. 

Crispe IN (2003) Hepatic T cells and liver tolerance. Nat Rev Immunol 3 51-62 Devillier P (2006) Comparing the new antihistamines the role of pharmacological parameters. Clin Exp Allergy 36 5-7... 

Doses should include and exceed the primary pharmacod5mamic or therapeutic range. In the absence of adverse effects on safety pharmacology parameters, highest tested doses should produce moderate adverse effects in this or other safety assessment studies. 

Kidney retention (toxicity) of Pt for < s-[Pt(NH3)2Cl2] is unaltered on varying basic pharmacological parameters such as dose and concentration of the administered oia-[Pt(NH3)2Cl2]. 

Binding equilibrium is reached dependent on concentrations of reactants ([A] + [R]) and the association (fej) and dissociation k rate constants of the AR complex. In equilibrium, the association and dissociation rates are equal (Eq. 2) thus, the equihbrium dissociation rate constant (Kj) is used as a pharmacological parameter representing the affinity of the ligand for the receptor (Eq. 3) ... 

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