Pharmacological differences between men and women

We are indebted to the authors from the first edition who have worked to update their chapters, but are sad to report that Mary Berg, author of the chapter on Pharmacological Differences between Men and Women, died on October 1, 2004. She was an esteemed colleague and effective advocate for studying sex differences in pharmacokinetics and... 

Wood S. Sex differences between men and women enrolled in clinical trials. In American Society for Clinical Pharmacology and Therapeutics educational symposium June 6-7, 2004. Washington, D.C. ASCPT 2004. 

Pharmacokinetics According to the product label, the pharmacokinetics of eptihbatide are linear and dose proportional. Plasma elimination half-life is approximately 2.5 hours. The extent of eptihbatide binding to human plasma protein is about 25% its mean volume of distribution is 185mPkg. Clearance in patients with coronary artery disease is 55-58 ml/kg per hour. Clinical studies have included 2418 patients with serum creatinine between 1.0 and 2.0mg/dl without dose adjustment. No data are available in patients with more severe degrees of renal impairment, but plasma eptihbatide levels are expected to be higher in such patients. Patients in clinical studies were older than the subjects in clinical pharmacology studies, and they had lower total body eptihbatide clearance and higher eptihbatide plasma levels. Men and women showed no important differences in the pharmacokinetics of eptihbatide. 

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