Pharmacological development

Minotti G, Menna P, Salvatorelli E et al (2004) Anthracyclines molecular advances and pharmacologic developments in antitumor activity and cardiotoxicity. Pharmacol Rev 56 185-229... 

Borel JF. (2002) History of the discovery of cyclosporin and of its early pharmacological development. Wien Klin Wochenschr 114 433 37. 

In conclusion, neurosteroid-based anxiolytics with low intrinsic toxicity may represent an exciting new pharmacological development with potential advantages over existing classes of anxiolytics with regard to tolerance, dependence, and abuse liability. 

A pharmacological development program embarked on by the drug company Rhone Poulenc in Paris to screen for medicaments having an antihistamine action. 

Due to its high potency and selectivity imetit (24) proved to be a valuable tool in pharmacological trials related to H3 receptors, but in spite of that the potential toxicity of its isothiourea moiety emerges to impede further pharmacological development. A similar situation arose with the H3 antagonist thioperamide, the clinical development of which was ceased due to hepatotoxicity which is most probably related to its thiourea functionality. 

Before entering into a clinical evaluation program, a drug candidate is subjected to a number of preclinical studies to further define and characterize its safety profile. The results from the pharmacology, developability, and preclinical studies are documented in technical reports or scientific publications and used to prepare the IND submission. All of the preclinical studies, described in the section below, and nonclinical studies, discussed in the following section, need to be conducted according to GLP regulations. 

Pharmacological Developments Likely to Enhance the Benefits of Pharmacoinvasive Therapy... 

Many of the pharmacological developments that are designed to enhance reperfusion have overlapping goals. Notable advances include improvements in each of the three major components of a pharmacological reperfusion regimen fibrinolytics, antithrombins, and antiplatelets (Fig. 7.1). The antithrombin and antiplatelet advances have also... 

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