Pharmacokinetics predictive models

Sinko, P. J., Grass, G. M., Development of predictive pharmacokinetic simulation models for drug discovery, /. Controlled Release 2000, 65, 55—62. 

Pharmacokinetic/pharmacodynamic model using nonlinear, mixed-effects model in two compartment, best described time course of concentration strong correlation with creatinine clearance predicted concentration at the efi ect site and in reduction of heart rate during atrial fibrillation using population kinetic approach... 

Pharmacokinetic/pharmacodynamic modeling indicates that the AUC/MIC ratio is predictive of outcome for this antibacterial suggesting that telithromycin is suitable for short-duration therapy and a once-daily dosing regimen even against / -lactam and macrolide-resistant pathogens... 

Gundertofte EK, Jorgensen, FS. Pharmacokinetics Molecular Modeling and Prediction Of Bioavailability, Kluwer Academic/Plenum Publishers, New York, 2000. 

Rnally, pharmacokinetic and pharmacokinetic/pharmacodynamic modelling can be used for the purpose of prediction of the concentration-time profile of the drug and drug-carrier conjugate after repeated administration from single dose data, as well as for the prediction of the dose needed to maintain the concentration at the target site within a therapeutic window. 

Physiologically-based pharmacokinetic (PBPK) models have been developed for a number of drugs and chemicals, in order to better understand and simulate the dynamics of those compounds in the body. Advances made to date indicate that valid PBPK models can accurately predict the... 

The selection of the appropriate population pharmacokinetic base model was guided by the following criteria a significant reduction in the objective function value (p < 0.01,6.64 points) as assessed by the Likelihood Ratio Test the Akaike Information Criterion (AIC) a decrease in the residual error a decrease in the standard error of the model parameters randomness of the distribution of individual weighted residuals versus the predicted concentration and versus time post start of cetuximab administration randomness of the distribution of the observed concentration versus individual predicted concentration values around the line of identity in a respective plot. 

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