Pharmacokinetics parameters that define pharmacokinetic profile

Parameters That Define Drug Pharmacokinetic Profile 90... 

Intravenous Drug Disposition. The estimation of primary pharmacokinetic parameters using noncompartmental analysis is based on statistical moment theory [45, 46]. The relationships dehned by this theory are valid under the assumption that the system is linear and time-invariant. For simplicity, we further assume that drug is irreversibly removed only from a single accessible pool (e.g., plasma space). Regardless of the route of administration, the temporal profile of plasma drug concentrations, Cp(t), can represent a statistical distribution curve. As such, the zeroth and first statistical moments (Mo and Mi) are defined as ... 

Compared to such correlations based on stratum comeum permeability studies, IPPSF profiles may have additional parameters related to penetrant interactions with nonlipid components of the skin. Earlier exploratory analyses indicated that the d parameter in the above model was most closely correlated to E = 0.67), suggesting it is a parameter related to stratum comeum permeability. Note, however, that in a pharmacokinetic model, the epidermal permeability coefficient is not a single rate constant but rather would be a microconstant defined by the model s differential eqnations. This is a limitation of using the empirical A,b,d modeling approach. 

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