Pharmacokinetics ideal” drugs

The Ideal Drug from the Point of View of Pharmacokinetics... 

From a pharmacokinetic perspective, proton pump inhibitors are ideal drugs they have a short serum half-life, they are concentrated and activated near their site of action, and they have a long duration of action. 

Ideal drug candidate for controlled release delivery systems. From a pharmacokinetic and pharmacodynamic perspective, the ideal drug candidate for controlled release delivery systems would have high potency and... 

From a pharmacokinetic perspective, proton pump inhibitors are ideal drugs they have a short serum half-life, they are concentrated and activated near their site of action, and they have a long duration of action. In contrast to H2 antagonists, proton pump inhibitors inhibit both fasting and meal-stimulated secretion because they block the final common pathway of acid secretion, the proton pump. In standard doses, proton pump inhibitors inhibit 90-98% of 24-hour acid secretion. 

An NCE (new chemical entity) rarely meets aU the requirements of an ideal drug substance. As lead optimization concentrates towards improvement of biological activity as evaluated by in vitro tests, other desirable properties often fall behind, although the awareness is increasing that acceptable pharmacokinetic properties should be built into a drug molecule as well. 

The ideal intravenous anaesthetic agent Mechanism(s) of intravenous anaesthesia Pharmacokinetics and metabolism Rapidly acting intravenous anaesthetics Non-barbiturate intravenous anaesthetics Slower-acting intravenous anaesthetics Other drugs INTRODUCTION... 

---