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Pharmacokinetic interactions distribution patterns

In conclusion, the macromolecular properties of polymers and their interactions with cell surfaces result in a specific pharmacokinetic behaviour of polymers. The routes of parenteral administration are far from being equivalent, e.g. the intraperi-toneal application often used cannot substitute the intravenous administration. Molecular parameters of the polymer circulating in the coitral compartment are changed in time not necessarily by a direct biological modification of the polymer but as a consequence of a selective processing of different fractions. The intracellular accumulation in secondary lysosomes is the only proven mode of persistence of a soluble polymer in tissues. Variations in the chemical structure of the polymer may result in a different pattern of polymer distribution in the body as a consequence of a different rate of cellular accumulation. [Pg.28]


See other pages where Pharmacokinetic interactions distribution patterns is mentioned: [Pg.533]    [Pg.620]    [Pg.331]    [Pg.25]    [Pg.631]    [Pg.1971]    [Pg.331]    [Pg.130]    [Pg.3668]    [Pg.593]    [Pg.130]    [Pg.631]   
See also in sourсe #XX -- [ Pg.3 ]




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