Pharmacogenetic Aspects

The congenital form of long QT syndrome is characterized by a prolonged QT interval in the electrocardiogram and TdP [28-30]. Many patients with this syndrome 

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Kumana CR, Chan M, Ko W, Lauder J, Lin HJ. 1987. Differences in diazepam pharmacokinetics in Chinese and White Caucasians relationship to body lipid stores . Eur. J. Clin. Pharmacol. 32 211-215. Kupfer A, Preisig R, Zeugin T. 1988. Pharmacogenetic aspects of biological variability . J. Gastroenterol. Hepatol. 3 623-633. 

Cacabelos R, Llovo R, Fraile C, Fernandez-Novoa L (2007) Pharmacogenetic aspects of therapy with cholinesterase inhibitors The role of CYP2D6 in Alzheimer s disease pharmacogenetics. Curr Alzheimer Res 4 479-500... 

Concerning pharmacogenetic aspects of hormone receptors, see the Endocrinology section in this chapter. 

Kupfer A, Preisig R, Zeugin T (1988) Pharmacogenetic aspects of biological variability. J Gastroenterol Hepatol 3 623-33. 

Another important aspect of pharmacogenetics is the realization that all phar-macogenetic variations studied to date occur at different frequencies among subpopulations of different ethnic or racial origin. For instance, striking cross-ethnic... 

There are three aspects of pharmacogenomics that make it different from classical pharmacogenetics. 

Bertilsson L, Dahl ML, Tybring G. Pharmacogenetics of antidepressants clinical aspects. Acta Psychiatr Scand Suppl 1997 391 14-21. 

Bertilsson, L., "Pharmacogenetics of Anti-depressants Clinical Aspects," Acta. Psychiat. Scand. Suppl., 391,14-21 (1997). 

Adopting innovative, proactive approaches (including emergent science such as pharmacogenetics and personal informatics) and learning from other social and industrial sectors (such as aviation) where safety is a core aspect of operations, for ... 

Eichelbaum M, Gross AS. The genetic polymorphism of debrisoquine/ sparteine metabolism—clinical aspects. In Kalow W, ed. Pharmacogenetics of drug metabolism. New York Pergamon Press Inc, 1992 625-648. 

Attention to interethnic differences has become a major aspect of pharmacogenetics (1-9) stimulated by studies of drug response and toxicity in various human populations who differed in their response, even when taking usually well tolerated doses of some common therapeutic chemicals. The purpose of this chapter is to indicate essential elements of this broad topic, and to provide examples of some of its important aspects. 

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