Pharmacoepigenetics From Basic Epigenetics to Therapeutic Applications

Pharmacoepigenetics From Basic Epigenetics to Therapeutic Applications [Pg.461]

The Krembil Family Epigenetics Laboratory, Centre for Addiction and Mental Health, Toronto, Ontario, Canada [Pg.461]

GENERAL PRINCIPLES OF EPIGENETIC REGULATION 1.1. Epigenetic Mechanisms [Pg.462]

There are two major mechanisms of epigenetic regulation, methylation of cytosines in the DNA sequence and modification of the histone proteins that the DNA is wrapped around. The co-ordination of both mechanisms results in dramatic changes in remodeling of chromatin and altered gene transcription. [Pg.462]

The DNMTs at least partially account for the interaction of DNA methylation with histone modification as these enzymes are able to directly recruit histone deacetylases (HDACs) and this is achieved by binding methylated C ( etQ binding proteins such as MeCP2, MBD1, MBD2, and MBD3 (detailed reviews in Refs. 24 and 25). [Pg.463]

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