Pharmaceuticals polymorphism

The majority of applications of solid state NMR used in the investigation of pharmaceutical polymorphs are performed in conjunction with other analytical... [Pg.111]

C. Starbuck, A. Spartalis, L. Wai, et al., Process optimization of a complex pharmaceutical polymorphic system via in situ Raman spectroscopy, Cryst. Growth Des., 2(6), 515-522 (2002). [Pg.456]

Pharmaceutical Polymorph screening, Unknown particle Tablet reconstruction,... [Pg.430]

Byrn et al. (1995) have offered strategic approaches for characterizing pharmaceutical solids with speciLc emphasis on regulatory considerations. The International Conference on Harmonisation (2000) and the FDA (2004) have also presented their guidance for industry on how to address the issues of pharmaceutical polymorphism. In general, the information that is useful at the early development phase includes... [Pg.535]

Starbuck, C. Spartalis, A. Wai, L. etal Process Optimization of a Complex Pharmaceutical Polymorphic System Via In Situ Raman Spectroscopy Cryst. Growth Des. 2002, 2, 515-522. [Pg.167]

Urakami K. Characterization of pharmaceutical polymorphs by isothermal calorimetry. Curr Pharm Biotechnol 2005 Jun 6(3) 193-203. [Pg.85]

Thermal analysis and infrared spectroscopy are applied to a number of pharmaceutical polymorphic systems (76) in another paper from Kuhnert-Brandstatter. In addition to the characterization of these systems by these two techniques, discussion is provided on the preparation of the modification from either various solvent systems or... [Pg.258]

N. Chieng, T. Rades, J. Aaltonen, An overview of recent studies on the analysis of pharmaceutical polymorphs, J. Pharm. Biomed. Anal. 55 (4) (2011) 618—644. [Pg.267]

R.K. Harris, Applications of solid-state NMR to pharmaceutical polymorphism and related matters, J. Pharm. Pharmacol. 59 (2) (2007) 225—239. [Pg.267]

I. Packing polymorphism is a redundant term. It has presumably been used to indicate different packing of the same compound, but the term polymorphism is exactly that. Bernstein has discussed the superfluous use of packing polymorphism and similarly redundant terms such as pharmaceutical polymorphism, synthon polymorphism, and structural poly-morphism. ... [Pg.2192]

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