Pharmaceutical applications hydrate polymorphism

Ab initio methods for polymorph, hydrate and solvate prediction are highly prized by the industry and good progress has been made in this field in recent years. This work is still a number of years from routine commercial application however, and polymorph screening experiments together with crystal structure determination, remain critical tasks for today s Pharmaceutical companies. 

Smith A. Pharmaceutical and biological applications of thermal analysis studies in polymorphism and hydration. Anal Proc 1986 23 338-389. 

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