Pharmaceuticals pentamidine

The supramolecular dendrimers and hyperbranched system considered in the previous section are assembled from identical dendrons and monomers that contain complementary noncovalent recognition motifs. In 1997, Zimmerman and coworkers produced a three-component dendrimer (36) whereby two dendrons (37) were brought together around a small dicationic core (38) by complementary electrostatic and hydrogen bonding interactions (Scheme 8). The ditopic core template is also a known pharmaceutical, pentamidine, which is active against Pneumocystis carinii pneumonia —a serious lung infection. Controlled disassembly of the dendrimer in vivo would result in increased... [Pg.2636]

N Williams, D Schwinke. Low temperature properties of lyophilized solutions and their influence on lyophilization cycle design pentamidine isethionate. PDA Journal of Pharmaceutical Science and Technology 48 135-139, 1994. [Pg.164]

S Chongprasert, U Griesser, A Bottorff, N Williams, S Byrn, S Nail. Effects of freeze-dry processing conditions on the crystallization of pentamidine isethionate. Journal of Pharmaceutical Sciences 87 1155, 1998. [Pg.165]

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