Pharmaceutical Aspects of Solubilisation

The presence of micelles and surfactant monomers in a drug formulation can have pronounced effects on the biological efficacy. Surfactants (both micelles and mono- 

The above effect has been analysed by Noyes and Whitney [14] the dissolution rate dC/dt depends on the surface area of the drug and its saturation solubility Cs, 

Higuchi [31, 32] assumed an equilibrium between solute and solution at the solid-solution interface. The rate of drug movement into the bulk is governed by the diffusion of the free solute (with a diffusion coefficient Dt) and the solubilised drug (with a diffusion coefficient Dm) across a stagnant diffusion layer of thickness h. 

Prediction of dissolution rates may be made using the Stokes-Einstein equation for D, 

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