Phagocytes reactive oxygen species produced

Since it is well recognized that reactive oxygen species produced by activated phagocytes are involved in inflammatory processes and can contribute to cell and tissue damage either directly or through activation of proteases,116... 

Figure 5.21 generation of free radicals and reactive oxygen species in a phagocyte. Note here the dependence on the PPP to produce NADPH... 

Reactive Oxygen Species Reactive intermediate oxygen spedes including both radicals and non-radicals. These substances are constantly formed in the human body and have been shown to kill bacteria and inactivate proteins, and have been impHcated in a number of diseases. Sdentific data exist that Hnk the reactive oxygen spedes produced by inflammatory phagocytes to cancer development. [NIH]... 

Forms of oxygen-derived species produced by activated phagocytes can cause considerable tissue damage unless limited by copper-zinc superoxide dismutase (SOD) which destroys superoxide, 02, or catalase which destroys H202. However, at least two, if not three, other reactive forms of oxygen need to be considered70,71. ... 

Whether another highly reactive species, singlet oxygen ( O2), is produced in significant quantities is uncertain. The production of singlet oxygen, however, does take place in the phagocytic vacuole. The rate is very slow because of the more alkaline pH in this vacuole (Kanofsky et ai, 1985). 

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