Phage therapy infection

Antibiotic-resistant bacteria can be destroyed with phage therapy that bathes infections with solutions containing phages (Svoboda, 2009). If the phages delivered are tailored to the specific type of bacteria to be controlled, then dramatic results can be obMned. 

Since the early 1920s these phages have been used in clinical practice (Abedon et al., 2011) however, interest in them decreased with the discovery of antibiotics. Nevertheless, the emergence of multidrug-resistant bacteria has opened a second window of opportunity for phage therapy in bacterial infections (Kutter et al 2010 Torres-Barcelo and Hochberg, 2016). 

Kutter, E., De Vos, D., Gvasalia, G., Alavidze, Z., Gogokhia, L., Kuhl, S., Abedon, S.T., 2010. Phage therapy in clinical practice treatment of human infections. Curr. Pharm. Biotechnol. 11,69-86. 

Pires, D.P., Vilas Boas, D., SiUankorva, S., Azeredo, J., 2015. Phage therapy a step forward in the treatment of Pseudomonas aeruginosa infections. J. Virol. 89, 7449-7456. 

Phage therapy of Edwardsiella tarda infection in loaches... 

Phage therapy of Vibrio harveyi infection in shrimp... 

Phage therapy of Aeromonas salmonicida infection in sahnonids... 

Phage therapy of Flavobacterium psychrophilum infection in trout... 

Phage therapy of Streptococcus iniae infection in yellowtail... 

During these challenge studies S. iniae strains re-isolated from dead fish were resistant to infection by the phages used. These resistant strains remained virulent to Japanese flounder when tested by i.p. injection at 10 CFU/fish. The authors indicate that there is a need for new phages that can kill these resistant strains, and that further investigations are required to establish phage therapy of 5. iniae infections in Japanese flounder. 

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