PGE2 inhibitory activity

The purpose of the review [8] was to describe four structurally similar stUbene compounds, piceataimol, pinosylvin, rhapontigenin, and pterostilbene, and detail some current pharmaceutical research and highlight their potential clinical applications. In the study [49], an extract of Pterocarpus marsupium Roxb. containing pterostilbene has been evaluated for its PGE2-inhibitory activity in LPS-stimulated... 

Furthermore, either PGD2 or a DPI receptor agonist decreases responses to mechanical stimulation in rats with inflamed joints and the facilitatory effects of PGE2, and the inhibitory effect of PGD2 could have been resulted from the activation of GABAergic inhibitory intemeurons (Eguchi et al., 1999 Minami... 

PGE2 production in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells. These inhibitory effects could explain the in vivo mechanism of the active methanol extract. 

PGE can stimulate or inhibit its own hormone-induced synthesis via an ability to stimulate cAMP production. In the canine renal collecting tubule there appear to be two PGE receptors ". One of these receptors is an inhibitory receptor which modulates vasopressin-induced H2O flow . The other receptor is coupled to stimulation of adenylate cyclase activity. This latter receptor may be involved in inhibition of arachidonate release and feedback inhibition of hormone-induced PGE production. Similarly, neutrophil activation (and PGE2 synthesis) induced by f-met-leu-phe is under feedback inhibitory control by a PGE receptor apparently coupled to The opposite situation occurs in the thyroid. In the thyroid, there are two phases to PGE synthesis. The second phase is cAMP dependent and PGE serves to augment its own synthesis by its ability to stimulate adenylate cyclase activity ... 

Comparison of the Inhibitory Potency on LPS-Induced PGE2 Production by the RAW264.7 Macrophage and the Reported Antioxidant Activity of Tested Phytochemicalsa... 

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