Pethidine Cimetidine

Pethidine Cimetidine Increased effect of pethidine Reduced metabolism... [Pg.2628]

ALFENTANIL, FENTANYL, PETHIDINE, TRAMADOL CIMETIDINE Cimetidine may t fentanyl, pethidine and tramadol levels Cimetidine inhibits CYP2D6-medi-ated metabolism of these opioids. Ranitidine weakly inhibits CYP2D6 Watch for excessive narcotization... [Pg.478]

The hepatic metabolism of pethidine can be inhibited by cimetidine, leading to respiratory depression and sedation (25,26). [Pg.2793]

Clinically important, potentially hazardous interactions with benzodiazepines, cimetidine, clomipramine, clorazepate, dextromethorphan, pethidine, selegiline, tyramine... [Pg.390]

No clinically significant interaction appears to occur between ci-metidine and butorphanol (intranasal), hydromorphone, morphine, pethidine or tramadol between famotidine and hydromorphone or between ranitidine and hydromorphone, morphine, or pethidine. However, isolated reports describe adverse reactions in patients taking methadone, morphine or mixed opium alkaloids with cimetidine, or morphine with ranitidine. [Pg.171]

Cimetidine 600 mg twice daily for one week reduced the total hody clearance of a single 70-mg intravenous dose of pethidine in 8 healthy subjects by a modest 22%." In a similar study by the same research group, ranitidine 150 mg twice daily had no effect on pethidine pharmacokinetics. ... [Pg.171]

Cimetidine inhibits the activity of the liver enzymes concerned with the A-demethylation of methadone and pethidine, reducing their metabolism, so they accumulate in the body, thereby exaggerating their respiratory depressant effects. A reduction in liver function might possibly have contributed towards, or even been largely responsible for the cases with methadone, because both patients were elderly. [Pg.171]

Information about the interaction between pethidine and cimetidine is very limited, and its clinical importance is uncertain, but probably small given the minor changes in pharmacokinetics. However, some manufacturers warn that cimetidine may inhibit the metabolism of pethidine and thus caution should be used with concurrent use. Ranitidine has been shown not to affect the pharmacokinetics of pethidine. [Pg.171]

Guay DRP, Meatherall RC, Chalmers JL, Grahame GR. Cimetidine alters pethidine disposition inman. BrJ Clin Pharmacol (1984) 18, 907-14. [Pg.172]

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