Petasites japonicus

Petasites japonicus F. Schmidt Feng Dou Cai (flower, root, leaf) Beta-sitosterol, beta-carotene, thiamine, riboflavin, niacin, ascorbic acid.50 For colds, asthma, cough, dyspnea, tuberculosis. 

Achyranthes asperia, Amaranthus tricolor, A. lividus, A. blitum, A. viridis, Benincase cerifera, B. hispida, Boehmeria densiflora, Canarium album, C. sinense, Castanea crenuta, C. mollissima, Corylus heterophylla, C. mandshurica, Petasites japonicus, Rosa multiflora, Syzygium aromaticum, Zea mays Urtica angustifolia, U. cannabina, U. lobata, U. tenacissima, U. urens, U. utillis Centella asiatica... 

C. sinense, Castanea crenuta, C. mollissima, Corylus heterophylla, C. mandshurica, Petasites japonicus, Zea mays... 

C. mandshurica, Glycine max, G. soja, Hibiscus rosa-sinensis, H. rhombifolius, Petasites japonicus, Syzygium aromaticum, Zea mays Nicotiana tabacum Nicotiana tabacum... 

PROP Dried flower stalk of Petasites Japonicus Maxim (GANNA2 64,527,73). 

Eremopetasidione (440), isolated recently from rhizomes of Petasites japonicus MAXIM, has been used in the treatment of tonsillitis, contusion and poisonous snake bites in Chinese medicine. Recently, racemic 440 was synthesized in 9 steps (30% overall yield) starting from 2-methoxy-4-methylphenol (421) (Scheme 85) . Oxidation of 421 with PhI(OAc)2 in MeOH in the presence of ethyl vinyl ketone (EVK) afforded in 96% yield a Diels-Alder adduct 441, which was converted into sUyl enolate 442 in 96% yield. This enolate further underwent Cope rearrangement to give regio- and stereoselectively the desired c -decalin 443 (70%). Further conversion of 443 to the target molecule 440 was then accomplished. 

Tussilago farfara (L ), coughwort, feuilles de tussilage, horse-hoof, huflattichblatter, kuandong hua (Anonymous, 1996), Petasites japonicus Maxim ("fuki-no-toh") (Hirono et al., 1973)... 

Hirono I, Shimizu M, Fushimi K, Mori H, Kato K. Carcinogenic activity of Petasites japonicus Maxim., a kind of coltsfoot. Gann 1973 64 527-8. 

Hirono I, Mori H, Yamada K, Hirata Y, Haga M, Takematsu H, Kanie S. Carcinogenic activity of petasitenine, a new pyrrolizidine alkaloid isolated from Petasites japonicus Maxim. J Natl Cancer Inst 1977 58 1155-6. 

Pancratium triathum (trianthine), 402 Petasites japonicus Maxim (petasinine), 242... 

Oil from flower stalk of Petasites japonicus. Defensive secretion of tenebrionid beetles. Fp -49.1°. Bp 192.7°, Bp,o73°. 

Plants containing 1,2-dehydro-pyrrolizidine alkaloids may cause liver necrosis to domestic animals and humans. Therefore, care must be taken not to consume plants that are known to contain pyrrolizidine alkaloids, such as the flower stalks of Petasites japonicus (Asteraceae),comfrey Symphytum officinale (Boraginaceae), and Borago officinalis (Boraginaceae). Lycopsamine was isolated as a main alkaloid of Russian comffey (a hybrid of S. officinale and Symphytum asperum) [5]. 

The petasiphenol is a natural phenolic compound produced from a higher plant, a Japanese vegetable (Petasites japonicus) that was originally found to be a bioantimutagen in UV-induced mutagenic Escherichia coli WP2 B/r Trp-isolated from the same plant [123]. It was established experimentally that petasiphenol binds to N-terminal BRCT domain of pol X with IC of 7.6 pM and does not bind to the C-terminal catalytic domain including the pol (l-like core of pol X [95],... 

Furuya, T., M. Hikichi, and Y. Iitaka Fukinotoxin, a New Pyrrolizidine Alkaloid from Petasites japonicus. Chem. Pharm. Bull. (Japan) 24, 1120 (1976). 

Yamada, K., H. Tatematsu, M. Suzuki, Y. Hirata, M. Haga, and I. Hirono Isolation and the Structures of Two New Alkaloids, Petasitenine and Neopetasitenine from Petasites japonicus Maxim. Chem. Lett. 1976, 461 Yamada, K., H. Tatematsu, Y. Hirata, M. Haga, and I. Hirono Stereochemistry of Petasitenine, the Carcinogenic Alkaloid from Petasites japonicus Maxim, and Transformation of Petasitenine to Senkirkine. Chem. Lett. 1976, 1123. 

Yamada, K., H. Tatematsu, R. Unno, and Y. Hirata Petasinine and Petasinoside, Two Minor Alkaloids Possessing a New Necine Isolated from Petasites japonicus Maxim. Tetrahedron Lett. 1978, 4543. 

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