Pesticide design

Ernest L. Plummer, The Application of Quantitative Design Strategies in Pesticide Design. 

I believe that John Siddall, whom this symposium commemorates would have approved of this view as representing a further component of the rational approach to pesticide design which his work so clearly represented. 

A Quantitative Structure-Activity Relationship Approach to Pesticide Design... 

Often environmental work can tolerate an estimation error of 0.5 log units in log P, but in this instance it was crucial for the correct mechanistic conclusion. This is the sort of information, then, which can be valuable to both the pesticide designer and the environmental toxicologist. 

At this point the history of the concept of hormonal control of insects should be recalled, since the major reasons for the selection of JH as a rational lead for pesticide design were the beliefs that JH occurred only in insects and not in other animals. The implication was that JH would therefore be selectively active in insects with no significant effects on other forms of life. In the cases of JH analogs of the farnesane skeleton, extensive studies of comparative toxicology have largely verified these beliefs. Toxicological results have been reviewed in detail (20 ) and a comprehensive study of the environmental fate and metabolism of methoprene has been completed (2 1). ... 

Fluorine-containing heterocyclic compounds play an important role in drug and pesticide design. The key methods of synthesis of these compounds are based on condensation and intramolecular cyclization processes induced by heteronucleophiles. They may affect the fluorine atoms of a benzene ring and the multiple bond of perfluoroolefins. Intramolecular cyclizations are characteristic of unsaturated polyfluorinated compounds. Therefore,... 

Applying carefully selected narrow-spectrum pesticides designed to manage pest populations while having minimal impact on beneficial species. 

CAS 1563-66-2. TM for a pesticide designed to combat com rootworm and rice water weevil. Approved by USDA. Also effective on alfalfa, sugarcane, rice, peanuts, and potatoes. 

Pesticide Design. Rational design of pesticides that are susceptible to cometabolic or chemical degradation in soil but that do not induce microbial biodegradative adaptation needs to be put into practice. 

Acidic Compounds. Included in the group of pesticides designated as acidic compounds are those chemicals which possess carboxyl or phe-... 

Takahashl, Y. Pesticide Design-Strategy and Tactics Eto, M. Ed Soft Science, Inc. 1979, 674. 

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