Persistent and very bioaccumulative

Persistent, Bioaccumulative and Toxic and Very Persistent and Very Bioaccumulative Substances... 

Authorisation will also be required for persistent, bioaccumulative and toxic (PBT) and very persistent and very bioaccumulative (vPvB) substances. The PBT and vPvB criteria are defined in Annex XII of the Regulation (Table 7). There are subtle differences in the... 

NOEC No-observed effect concentration vPvB Very persistent and very bioaccumulative... 

This is also accounted for in the planned EU chemicals regulation. Substances that are very persistent and very bioaccumulative can be introduced subject to authorisation, even when there are no scientifically based indications of (eco)toxicological effects. 

These relationships allow for screening and ranking of toxicity so that the least toxic option may be used if deemed appropriate. They are applied in many jurisdictions for regulatory use in the prediction of ecological effects (and fate) of chemicals when there are no actual toxicity data and decisions need to be made about their use [99]. QSARs have been developed, for example, to predict which chemicals may exhibit persistence, bioaccumulation, and toxicity (PBT) properties, or be very persistent and very bioaccumulative (vPvB) [99]. These methods have been applied to the prediction of chemicals that fall under the European REACH initiative and also high production volume (HPV) chemicals [99]. Currently available QSARs for predicting a compound s fall into two general classes those that have been developed for a nonspecific mode of action, and those that have been developed for specific types or classes of chemicals [99]. 

If the pharmaceutical fulfills the criteria for PBT (Persistent, Bioaccumulative and Toxic) and/or vPvB (very Persistent and very Bioaccumulative), the following phrase is added The substance fulfills the EU criteria for PBT/vPvB classification. 

Predictions for very persistent and very bioaccumulative (VPVB) substances using physico-chemical parameters and the EUSES model often result in false-positive values [136]. 

A Chemical Safety Report that documents chemical risk assessments must be prepared for substances that a company manufactures or imports at >10 tonnes per year. If a substance is identified as dangerous or very persistent and very bioaccumulative (VPVB), a set of exposure scenarios detailing the relevant risk management measures necessary to reduce exposures must be attached as an Annex to existing Safety Data Sheets. 

Vereinte Dienstleistungsgewerkschaft Very persistent and very bioaccumulative Dutch Ministry of Housing, Spatial Planning and the Environment... 

Substances being very persistent and very bioaccumulative. 

In an individual concentration of >0.1 % by weight for non-gaseous preparations at least one substance that is persistent, bioaccumulative and toxic or very persistent and very bioaccumulative in accordance with the criteria set out in Annex Xni or has been included in the authorization list for other reasons or... 

Criteria for the Identification of Persistent, Bioaccumulative, and Toxic Substances (PBT substances) and Very Persistent and Very Bioaccumulative Substances (vPvB substances)... 

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