Permethylated oligosaccharide, mass

Permethylated oligosaccharides also provide increased ion signals over their underivatized counterparts, allowing the sensitive analysis of minor components.142,145,146 This method provides a smaller mass increase and a greater volatility than the peracetylation method,147 however the use of peracetylation... 

Viseux, N., de Hoffmann, E. and Domon, B. (1997) Structural assignment of permethylated oligosaccharide subunits using sequential tandem mass spectrometry. Anal. Chem., 69, 3193-8. 

Solouki, T., Reinhold, B.B., Costello, C.E. et al. (1998) Electrospray ionization and matrix-assisted laser desorption/ionization Fourier transform ion cyclotron resonance mass spectrometry of permethylated oligosaccharides. Anal. Chem., 70 (5), 857-64. 

The most easily recognizable fragment ions in the mass spectra of permethylated oligosaccharide alditols are those from nonreducing units, i.e., fragment ions at m/z 219 for permethylated hexose, m/z 189 for permethylated deoxyhexose, m/z 175 for permethylated pentose, m/z 233 for permethylated... 

Much of our knowledge on the fragmentation patterns of carbohydrate derivatives arises from studies on methylated monosaccharides, but in structural investigations, such compounds are seldom subjected to mass spectrometry. On the other hand, the molecular weight of a permethylated oligosaccharide is significantly less than that of the per(trimethylsilyl) derivative. For this reason, the mass spectra of disaccharides as -their permethylated alditols have been determined by Chizhov and coworkers, Karkkainen, and Krone and Beckey. Trisaccharides have also been studied by Karkkainen, either as permethylated glycosides or as alditols. ... 

Viseux, N., Costello, C. E. andDomon, B. Post-source decay mass spectrometry optimized calibration procedure and structural characterization of permethylated oligosaccharides. JMass Spectrom, 34,364,... 

N. Viseux, E. de Hoffmann, and B. Domon, Structural analysis of permethylated oligosaccharides by electrospray tandem mass spectrometry. Anal Chem. 69, 3193-3198 (1997). 

Zhao, C. Xie, B. Chan, S. Y. Costello, C. E. O Connor, P. B. CollisionaUy activated dissociation and electron capture dissociation provide complementary structural information for branched Permethylated Oligosaccharides. J. Am. Soc. Mass Spectrom. 2008, 19, 138-150. 

Lemoine, J. Fournet, B. Despeyroux, D. Jennings, K. R. Rosenberg, R. de Hoffmann, E. Collision-induced dissociation of alkali metal cationized and permethylated oligosaccharides Influence of the collision energy and of the collision gas for the assignment of linkage position. J. Am. Soc. Mass Spec. 1993, 4(3), 197-203. 

Morelle, W. Slomianny, M. C. Diemer, H. Schaeffer, C. Dorsselaer, A. V. Michalski, J. C. Fragmentation characteristics of permethylated oligosaccharides using a matrix-assisted laser desorption/ionization two-stage time-of-flight (TOF/ TOF) tandem mass spectrometer. Rapid Common. Mass Spectrom. 2004,18, 2637-2649. 

A. Dell, Preparation and desorption mass spectrometry of permethyl and peracetyl derivatives of oligosaccharide, Meth. Enzymol., 193 (1990) 647-660. 

J. Delaney, P. Vouros, LC ion trap MS analysis of oligosaccharides using permethylated derivatives. Rapid Commun. Mass Spectrom., 15 (2001) 325. 

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