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Permeability Class 1 drugs: high solubility

BCS Class III High-solubility, low-permeability drugs. Absorption is permeability-rate limited but dissolution will most likely occur very rapidly. For this reason,... [Pg.199]

Class 1 Drugs High solubility-High permeability ... [Pg.29]

Class I — High solubility-high permeability drugs ... [Pg.43]

BCS Class I High-solubility, high-permeability drugs. BCS Class I drugs are generally very well absorbed. An immediate release (IR) product of this class is... [Pg.35]

Cheng, C.L., Yu, L.X., Lee, H.L., Yang, C.Y., Lue, C.S. and Chou, C.H. (2004) Biowaiver extension potential to BCS Class III high solubility-low permeability drugs bridging evidence for metformin immediate-release tablet European Journal of Pharmaceutical Sciences, 22 (4), 297. [Pg.46]

The BCS classes are defined as follows Class I. High Solubility (S) - High Pe Class II. Low S - High Peff Class III. High S - Low P( (T Class IV. Low S - Low Per(. A drug is considered as highly permeable when the extent of absorption is complete in humans, defined by the US FDA as being more than 90%, whereas EMEA requires... [Pg.541]

Cheng C, Yu L, Lee H, Yang C, Lue C, and Chou C. Biowaiver Extension Potential to BCS Class 111 High Solubility-Low Permeability Drugs Bridging Evidence for Metformin Immediate-release Tablet. Eur J Pharm Sci 2004 22 297-304. [Pg.249]

Class I Drugs (High Solubility and High Permeability)... [Pg.363]

One example of the application of response surface analysis is a study of critical formulation variables for 20 mg piroxicam capsules [100]. Piroxicam is a BCS Class II drug (low solubility and high permeability). This... [Pg.371]

BCS Class II Low-solubility, high-permeability drugs. The bioavailability of products containing these compounds is likely to be dissolution-rate limited. For this reason, a correlation between in vivo bioavailability and in vitro dissolution rate (IVIVC) may be observed. [Pg.199]

Fig. 15.5. The biopharmaceutics classification system (BCS). Drug-like molecules are grouped into four BCS classes based on their solubility and permeability. A drug is regarded as a highly soluble compound if the maximum dose given orally is soluble in 250 mL fluid in the... Fig. 15.5. The biopharmaceutics classification system (BCS). Drug-like molecules are grouped into four BCS classes based on their solubility and permeability. A drug is regarded as a highly soluble compound if the maximum dose given orally is soluble in 250 mL fluid in the...
Class I — Drug is highly soluble and highly permeable... [Pg.29]

See other pages where Permeability Class 1 drugs: high solubility is mentioned: [Pg.413]    [Pg.633]    [Pg.147]    [Pg.363]    [Pg.20]    [Pg.199]    [Pg.29]    [Pg.87]    [Pg.962]    [Pg.43]    [Pg.36]    [Pg.171]    [Pg.364]    [Pg.351]    [Pg.505]    [Pg.364]    [Pg.209]    [Pg.515]    [Pg.517]    [Pg.520]    [Pg.525]    [Pg.29]    [Pg.327]    [Pg.666]   


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Permeability class drug

Solubility classes

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