Piroxicam capsules

Oral 600 mg tablets, capsules Piroxicam (generic, Feldene)... 

One example of the application of response surface analysis is a study of critical formulation variables for 20 mg piroxicam capsules [100]. Piroxicam is a BCS Class II drug (low solubility and high permeability). This... 

All piroxicam batches were manufactured in compliance with Good Manufacturing Practices, and three formulations having fast, moderate, and slow dissolution were chosen for comparison to a lot of the innovator s product in a human bioavailability study [100]. The resulting pharmacokinetic data provided still another opportunity to examine the effects of formulation variables. To explore the relationship between the in vitro dissolution of piroxicam from these capsules and in vivo absorption, Polli [ 102] used the following previously described [145] deconvolution-based model ... 

Fig. 25 Response surfaces for the effect of formulation variables on percent of piroxicam dissolving from capsules in 10 minutes. (From Ref. 100.)...

Table 6 Apparent Permeability and Dissolution Rates for Piroxicam Capsules...

DA Piscitelli, S Bigora, C Propst, S Goskonda, P Schwartz, L Lesko, L Augsburger, D Young. The impact of formulation and process changes on in vitro dissolution and bioequivalence of piroxicam capsules. Pharm Devel Tech 3(4) 443-452, 1998. 

Shangraw, R. F.. and Demarest, D. Survey of current industrial practice in the formulation and manufacture of tablets and capsules. Pharm. Tech. 17(l) 32-44, 1993. USP 24-NF 19. United States Pharmacopoeia Convention, Inc. Rockville. MD, 2000. Piscitelli, D. A.. Bigora, S., Propst, C.. Goskonda, S., Young. D.. et al. Impact of formulation process changes on in vitro dissolution and the bioequivalence of piroxicam capsules. Phaim. Dev. Technol. 3 443 52, 1998. 

The adverse effects profile of suppositories, soluble tablet formulations, and standard capsules are similar (SEDA-13, 83). A parenteral formulation of piroxicam caused somnolence more often than diclofenac in a doubleblind study, but diclofenac provoked more gastric discomfort and nausea than piroxicam. Local adverse effects of both drugs were pain, burning, and induration at the site of injection (SEDA-15, 103). 

Swanepoel E, Liebenberg W, de Villiers MM, and Dekker TG. Dissolution Properties of Piroxicam Powders and Capsules as a Function of Particle Size and the Agglomeration of Powders. Drug Dev Ind Pharm 2000 26 1067-1076. 

Extraction of piroxicam from plasma, subcutaneous tissue or synovial [44] capsule homogenate, synovial fluid from alkaline medium with CH2CI2/ hexane (1 4) and evaporation of the extract, with the residues dissolved in mobile phase Linearity 0.72-600 ng/ml... 

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