Peripheral neuropathies falling

In a retrospective analysis of 36 patients who switched from stavudine to tenofovir while HIV RNA was below 20 copies/ ml for more than 6 months, two switched because of peripheral neuropathy and 34 because of lipoatrophy the median duration of observation was 36 weeks (158). There was a significant fall in cholesterol concentrations from 5.5 mmol/1 to 5.0 mmol/1 at week 4, and 4.7 mmol/1 at week 36. There was also a non-significant trend toward a fall in triglyceride concentrations. 

To prevent severe birth defects and possible death of the newborn child, when thalidomide is used in women of child-bearing age or in sexually active men (due to levels of thalidomide in semen) adherence to strict guidelines adopted by the FDA is required. The specific guidelines fall under the term S.T.E.RS. program or System for Thalidomide Education and Prescribing Safety . All prescribers (physicians) and distributors (pharmacists, etc.) must register and adhere to these guidelines. Other toxicides include headache, dizziness, rash, pruritis, drowsiness, somnolence, peripheral neuropathy, leucopenia, and venous thrombosis. 

Peripheral neuropathies can cause falling due to both weakness from motor-nerve involvement and impaired balance from sensory-nerve deficits these defects are often concurrent. 

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