Peril, defined

Generally speaking, the investigator carries out such simulations to show whether the postulated scheme matches the data. To carry out the simulations, the researcher fixes the rate constants of some steps at their established values and evaluates the ones that are unknown by iterative adjustment, the criterion being the quality of the match. Obviously, one is not likely to produce a definitive answer if too many steps have rate constants that are allowed to be adjusted at will. One may also be tempted to adjust one (more ) of the supposedly established rate constants. This action is perilous, without independent cause for suspicion. In that event, one should very seriously consider replicating the original experiments that defined that step. Not to do so invites the construction of an unsound house of cards. ... 

The second kind of insurance products that stimulate adaptation is based on the availability of capital to cope with catastrophes. These are financial arrangements intended to bring needed capital that will reduce the risk that could derive from future climate-related hazards for those who are most likely to be in peril. These products can be defined as adaptation oriented because they help to build the capacity of nations, communities, and businesses to cope with climate change impacts. 

In the ascending bubble problem (Example 8), the requirement that the pressure at the surface should be positive rules out the dramatic behavior near the singular curve ( = but, by suitably defining the value of the derivative at the discontinuity, solution paths of perilous stability can be found4 (Cf. [312]). In Fig. 13, the broken line A = 0 is manifestly unstable. However, the broken line B = 0 can be reached in a finite time by a solution starting above A = 0 in the lower part of the phase plane and below A - 0 in the upper part. If the value at the singularity, B = 0, which is otherwise undefined, is correctly chosen, the solution turns and follows the path B = 0. In practice, it falls victim to the peril, even when stable. 

The overall aim of the phase II studies is to define the type of studies that will be conducted in phase III, including dose, dnration of dosing, freqnency of dosing, patient population, and primary variable. When this evalnation is poorly conducted, the phase III outcome becomes much more of a guessing game than is necessary. Additional time spent in phase II to establish the best design for phase HI is likely to be returned by a shorter snc-cessful phase HI. Companies that truncate phase II so that they can start pivotal phase III studies as early as possible do so at their own peril. The end resnlt is often a case of more haste, less speed. 

Danger is defined as liability or exposure to harm something that causes peril. ... 

Colloquially, risk is defined as danger, hazard, peril—exposure to death, injury, loss, or some other negative consequence. Thus, risk implies an unrealized potential for harm. If the danger is actually realized, then it is no longer risk but actual death, injury, loss, or other harmful consequence. 

---