Pericosines from Periconia byssoides

The chlorocyclohexene derivative from the marine microorganism Periconia byssoides, pericosine A (170), is 33 times more cytotoxic in the P-388 lymphocytic leukemia test (IC50 0.12 pg/ml) than the corresponding methoxy compound [131]. 

Pericosines A (216) and B have been isolated from a strain of Periconia byssoides, originally separated from the sea hare Aplysia... 

Yamada T, Iritani M, Ohishi H, Tanaka K, Minoura K, Doi M, Numata A. Pericosines, antitumour metabolites from the sea hare-derived fungus Periconia byssoides. Structures and biological activities. Org. Biomol. Chem. 2007 5(24) 3979-3986. 

Here again, there has been little work on the metabolites of fungi associated with mollusks. Isolated from the sea hare, Aplysia kurodai, the fungus Periconia byssoides produces in culture two cytotoxic derivatives, pericosines A and H, and four trilactones, macrosphelides E-H, which are devoid of activity (Numata et al, 1997b). The cytotoxicity of pericosines A and B on P-388 is notable with... 

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